The minor allele ''C'' was associated with lower alcohol consumption in the non-alcoholic controls (p = 0.081), and independently in the alcohol-dependent cases (p = 0.046) [R].

''C'' allele confers a risk for esophageal squamous cell carcinoma (ESCC). A significantly increased ESCC risk is associated with the TC or CC genotype compared with the TT genotype was observed (OR = 1.35; P = 0.016; OR = 3.59; P<0.001). The presence of the CG or GG genotype was also associated with an increased risk of ESCC (OR = 1.70 or OR = 5.50 respectively) [R].


Parent Gene: ADH1C

Importance: 2
Less common allele: C = 48%
More common allele: T = 52%
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