The AA and AG genotypes had a significant prognostic effect on survival in advanced stage non-small-cell lung cancer (NSCLC) patients (HR, 1.482;P = 0.0034) [R].

For non-Caucasians, the GG homozygote may have higher cancer risk compared with either ''A'' allele carriers (OR: 1.58) or AA homozygote (OR: 1.43) [R].

The GG genotype was significantly associated with the decreased overall survival in oral squamous cell carcinoma (OSCC) patients (p = 0.010) [R].

The ''G'' allele was increased in Henoch-Schönlein purpura (HSP) patients with nephritis compared with healthy controls (p = 0.02, OR 2.13) [R].

The homozygous mutant type AA genotype was found with significantly higher frequency in the hypertensive nephropathy patients than in controls [R].

The GA + AA genotypes were associated with reduced ejection fraction (p = 0.008) in patients with systemic hypertension [R].

The AA genotype was associated with poor responders (PR) in both postoperative erectile dysfunction (PED) and clinical erectile dysfunction (CED) patients (P<0.05) [R].

Women carriers of AG + AA genotypes had a reduced risk to develop breast cancer (BC) [p = 0.018, OR 2.25] [R].

Carriers of  the mutant ''A'' allele were supposed to have a significantly elevated tetralogy of Fallot (TOF) risk [R].


Parent Gene: VEGFA

Importance: 2
Less common allele: A = 19%
More common allele: G = 81%
My Genotype: Log In