rs1558902 is a SNP in the FTO gene. It is associated with a higher BMI (Body mass index) than normal.

The ''A'' allele was substantially less common in young and middle aged Japanese women (18 and 17% respectively), than in the European population (45%).

The strong effect of genotype AA on BMI (body-mass index) was evident at age 12, 15, 20 and 50 years whereas there was no effect on birth weight .This variant was associated with higher odds of overweight (BMI ≥25 kg/m(2)) in young (OR 1.73) and middle-aged women (OR 1.73), abdominal fat accumulation (abdominal girth ≥90 cm, OR 1.73) and fasting hyperglycemia (≥100 mg/dL) (OR 1.87) in middle-aged mothers [R].

Body mass index (BMI) was higher in the TA+AA genotypes than in wild TT genotypes (P = 0.038) [R].

The ''A'' allele was associated with an increase of C-reactive protein (CRP) and a decrease in high-density lipoprotein (HDL) cholesterol [R].


 

rs1558902

Parent Gene: FTO

Importance: 5
Less common allele: A = 23%
More common allele: T = 77%
My Genotype: Log In
Risk Allele: A, T, A, A, A, A, A, A, A, A, A, A, A, A, A, A, A, A, A, A, A, A, A, A

Disease/Trait: Waist Circumference

rs1558902 is associated with Waist Circumference (R) . It is reported to association with Waist circumference. No specific risk allele was identified in the study.

Disease/Trait: Obesity

The T allele of rs1558902 is reported to be associated with Obesity (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Obesity.

Disease/Trait: Obesity

The A allele of rs1558902 is reported to be associated with Obesity (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Obesity (early onset extreme).

Disease/Trait: Obesity

The A allele of rs1558902 is reported to be associated with Obesity (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Obesity (Overweight).

Disease/Trait: Body Mass Index

The A allele of rs1558902 is reported to be associated with Body Mass Index (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Body mass index.

Disease/Trait: Body Mass Index

The A allele of rs1558902 is reported to be associated with Body Mass Index (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Body mass index.

Disease/Trait: Body Mass Index

The A allele of rs1558902 is reported to be associated with Body Mass Index (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Body mass index (age 8).

Disease/Trait: Body Mass Index

The A allele of rs1558902 is reported to be associated with Body Mass Index (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Body mass index (age 1-17).

Disease/Trait: Longitudinal Bmi Measurement

The A allele of rs1558902 is reported to be associated with Longitudinal Bmi Measurement (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Body mass index (age interaction).

Disease/Trait: Body Mass Index

The A allele of rs1558902 is reported to be associated with Body Mass Index (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Body mass index (EA, men).

Disease/Trait: Body Mass Index

The A allele of rs1558902 is reported to be associated with Body Mass Index (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Body mass index (EA, women).

Disease/Trait: Body Mass Index

The A allele of rs1558902 is reported to be associated with Body Mass Index (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Body mass index (EA).

Disease/Trait: Height-Adjusted Body Mass Index

The A allele of rs1558902 is reported to be associated with Height-adjusted Body Mass Index (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Height adjusted BMI.

Disease/Trait: Body Mass Index

The A allele of rs1558902 is reported to be associated with Body Mass Index (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Childhood body mass index.

Disease/Trait: Body Fat Percentage

The A allele of rs1558902 is reported to be associated with Body Fat Percentage . Your genotype was not identified for this SNP so we are unable to comment on your association with Body fat percentage.

Disease/Trait: Body Fat Percentage

The A allele of rs1558902 is reported to be associated with Body Fat Percentage . Your genotype was not identified for this SNP so we are unable to comment on your association with Body fat percentage (women).

Disease/Trait: Body Fat Percentage

The A allele of rs1558902 is reported to be associated with Body Fat Percentage . Your genotype was not identified for this SNP so we are unable to comment on your association with Body fat percentage (European).

Disease/Trait: Body Fat Percentage

The A allele of rs1558902 is reported to be associated with Body Fat Percentage . Your genotype was not identified for this SNP so we are unable to comment on your association with Body fat percentage (European women).

Disease/Trait: Body Fat Percentage

The A allele of rs1558902 is reported to be associated with Body Fat Percentage . Your genotype was not identified for this SNP so we are unable to comment on your association with Body fat percentage (European men).

Disease/Trait: Body Fat Percentage

The A allele of rs1558902 is reported to be associated with Body Fat Percentage . Your genotype was not identified for this SNP so we are unable to comment on your association with Body fat percentage (men).

Disease/Trait: High Density Lipoprotein Cholesterol Measurement

The A allele of rs1558902 is reported to be associated with High Density Lipoprotein Cholesterol Measurement (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with C-reactive protein levels or HDL-cholesterol levels (pleiotropy).

Disease/Trait: C-Reactive Protein Measurement

The A allele of rs1558902 is reported to be associated with C-reactive Protein Measurement . Your genotype was not identified for this SNP so we are unable to comment on your association with C-reactive protein levels or HDL-cholesterol levels (pleiotropy).

Disease/Trait: Waist Circumference

The A allele of rs1558902 is reported to be associated with Waist Circumference (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Waist circumference (EA, women).

Disease/Trait: Waist Circumference

The A allele of rs1558902 is reported to be associated with Waist Circumference (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Waist circumference (EA).

Disease/Trait: Waist Circumference

The A allele of rs1558902 is reported to be associated with Waist Circumference (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Waist circumference (EA, men).

Disease/Trait: Age At Menarche

rs1558902 is associated with Age At Menarche (R) . It is reported to have a 0.031 unit increase on Menarche (age at onset). No specific risk allele was identified in the study.