rs1558902 is a SNP in the FTO gene. It is associated with a higher BMI (Body mass index) than normal.
The ''A'' allele was substantially less common in young and middle aged Japanese women (18 and 17% respectively), than in the European population (45%).
The strong effect of genotype AA on BMI (body-mass index) was evident at age 12, 15, 20 and 50 years whereas there was no effect on birth weight .This variant was associated with higher odds of overweight (BMI ≥25 kg/m(2)) in young (OR 1.73) and middle-aged women (OR 1.73), abdominal fat accumulation (abdominal girth ≥90 cm, OR 1.73) and fasting hyperglycemia (≥100 mg/dL) (OR 1.87) in middle-aged mothers [R].
Body mass index (BMI) was higher in the TA+AA genotypes than in wild TT genotypes (P = 0.038) [R].
The ''A'' allele was associated with an increase of C-reactive protein (CRP) and a decrease in high-density lipoprotein (HDL) cholesterol [R].