rs1477196 is a SNP in the FTO gene. It is significantly associated with obesity .

Recently a clinic-based case control study revealed its association with breast cancer risk [R].

Carriers of the ''G'' allele had an increased risk of obesity when compared to those with the ''A'' allele (OR=2.07, P = 2.0 × 10(-4)) [R].

The ''G'' allele was associated with a 1.22 (0.38) increase in BMI (body-mass index) per risk allele in the low-activity group (P =.001) but only a 0.27 (0.31) increase in BMI in the high-activity group (P =.38) (interaction P =.004). Thus it was associated with obesity in the low-activity group (OR, 1.58 for each risk allele; P=.001) but not in the high-activity group (P =.11).[R].


Parent Gene: FTO

Importance: 2
Less common allele: A = 27%
More common allele: G = 73%
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