rs1433099 is a SNP in the LDLR gene. It is strongly associated with heart diseases like coronary artery disease (CAD) in the Japanese [R].

The incidence of coronary heart disease (CHD) was increased in African Americans with one or two copies of the ''T'' allele. When contrasted to participants not carrying a copy of the T allele, carrying 1 copy of the T allele was associated with a 23% increased risk of CHD, while carrying 2 copies was associated with a 47% increase in risk of CHD events (HR 1.38, p=0.02) [R].

The minor allele ''T'' was significantly associated with Myocardial infarction (MI) [R1, R2].


Parent Gene: LDLR

Importance: 2
Less common allele: T = 36%
More common allele: C = 64%
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