rs14158 is linked to the LDLR gene. It is associated with an increased response against hepatitis C virus (HCV) infection.

Patients with the GG genotype less commonly showed plasma hepatitis C virus-RNA (HCV-RNA) load at least 600000 IU/ml (P = 0.047) and lower likelihood of relapse of hepatitis C (P = 0.023) [R].

The GG genotype was associated with a higher rate of sustained virological response (SVR), and these effects were complementary in both HCV-monoinfected and HIV/HCV-coinfected patients [R].


Parent Gene: LDLR

Importance: 2
Less common allele: A = 23%
More common allele: G = 77%
My Genotype: Log In