- lower levels of HTR1B protein. The T allele generally signals a lower production of HTR1B. The T allele enables a microRNA-mediated reduction in expression (T) (R).
- Higher levels of Htr1B protein. The C allele causes microRNA to no longer be able to reduce expression (C) (R).
The Minor "C" allele is associated with:
- Decreased aggression and anger in men and women due to higher levels of HTR1B (R).
The Major "T" allele is associated with:
- Increased levels of hostile emotions due to lower levels of HTR1B (especially in TT) (R).
- Women with TT reported a history of more aggressive behaviors (starting fires, damaging property, and fighting) than C-allele carrier women (R).