Mechanism:

  •  lower levels of HTR1B protein. The T allele generally signals a lower production of HTR1B. The T allele enables a microRNA-mediated reduction in expression (T) (R).
  • Higher levels of Htr1B protein. The C allele causes microRNA to no longer be able to reduce expression (C) (R).

The Minor "C" allele is associated with:

  • Decreased aggression and anger in men and women due to higher levels of HTR1B (R).

The Major "T" allele is associated with:

  • Increased levels of hostile emotions due to lower levels of HTR1B (especially in TT) (R). 
  • Women with TT reported a history of more aggressive behaviors (starting fires, damaging property, and fighting) than C-allele carrier women (R).

 

rs13212041

Parent Gene: HTR1B

Importance: 3
Less common allele: C = 28%
More common allele: T = 72%
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