rs13181 is a SNP of the ERCC2 gene. It is significantly associated with lung cancer risk and other cancer types.

The variant ''G'' allele is associated with increased melanoma risk (OR = 1.12, P = 0.01; population attributable risk = 9.6%) [R].

rs13181 may be associated with an increased risk of ovarian carcinoma [R].

rs13181 was associated with oral cancer (OC) [R]. 

The ''T'' allele was associated with a 23% reduction in glioblastoma risk (P = 0.03) [RR1R2R3].

Statistically significant increase in Squamous Cell Carcinomas of the Head and Neck (SCCHN) risk was associated with ''GG'' (OR 1.680), ''TG'' (OR 1.531) and combined ''TG + GG'' (OR 1.560) genotypes [R]. 

The ''G'' allele was associated with an increased risk of acute myeloid leukemia (AML) (OR = 1.505) [R]. 

The heterozygote ''TG'' was significantly associated with the male  primary open-angle glaucoma (POAG) patients (z = 3.00 [p < 0.001]) [R].

Individuals carrying the ''G'' allele were more susceptible to breast cancer risk due to the effects of occupational radiation [R].

Individuals with the combined ''TG/GG'' genotypes were at an increased risk for lung adenocarcinoma compared with those carrying the ''TT'' genotype (OR=1.64) [RR1]. 

''TG+GG'' genotypes together were associated with an increased risk of gallbladder cancer [R].

The ''G'' allele was associated with reduced response and poor progression-free survival (PFS) and overall survival (OS) in Caucasians with colorectal and gastric cancer (PFS: HR = 1.41 and OS: HR = 1.42) [RR1R2R3].

In a Han ethnic the ''G'' allele was associated with a borderline decrease of esophageal squamous cell carcinoma (ESCC) (OR: 0.362), however, it was associated with ESCC risk in Uygur ethnic (OR: 2.403) [R].

Compared to those with BMI <25, women with BMI ≥25 had significantly increased risk of non-Hodgkin lymphoma (NHL) among women who carried the ''TT'' genotype [R]. 


Parent Gene: ERCC2

Importance: 5
Less common allele: G = 24%
More common allele: T = 76%
My Genotype: Log In
Risk Allele: C

Disease/Trait: Lung Carcinoma

The C allele of rs13181 is reported to be associated with Lung Carcinoma (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Lung Cancer (DNA repair capacity).