rs13181 is a SNP of the ERCC2 gene. It is significantly associated with lung cancer risk and other cancer types.
The variant ''G'' allele is associated with increased melanoma risk (OR = 1.12, P = 0.01; population attributable risk = 9.6%) [R].
rs13181 may be associated with an increased risk of ovarian carcinoma [R].
rs13181 was associated with oral cancer (OC) [R].
Statistically significant increase in Squamous Cell Carcinomas of the Head and Neck (SCCHN) risk was associated with ''GG'' (OR 1.680), ''TG'' (OR 1.531) and combined ''TG + GG'' (OR 1.560) genotypes [R].
The ''G'' allele was associated with an increased risk of acute myeloid leukemia (AML) (OR = 1.505) [R].
The heterozygote ''TG'' was significantly associated with the male primary open-angle glaucoma (POAG) patients (z = 3.00 [p < 0.001]) [R].
''TG+GG'' genotypes together were associated with an increased risk of gallbladder cancer [R].
The ''G'' allele was associated with reduced response and poor progression-free survival (PFS) and overall survival (OS) in Caucasians with colorectal and gastric cancer (PFS: HR = 1.41 and OS: HR = 1.42) [R, R1, R2, R3].
In a Han ethnic the ''G'' allele was associated with a borderline decrease of esophageal squamous cell carcinoma (ESCC) (OR: 0.362), however, it was associated with ESCC risk in Uygur ethnic (OR: 2.403) [R].
Compared to those with BMI <25, women with BMI ≥25 had significantly increased risk of non-Hodgkin lymphoma (NHL) among women who carried the ''TT'' genotype [R].