Mechanism:

  • Weaker response sensitivity to a neural signal (G) [R]

  • Normal neural signaling (A) [R]

The “G” (minor) allele is associated with:

  • Increase risk of developing Schizophrenia in GG [R].

  • Slight increase of risk of developing Schizophrenia in GA [R].

  • Nicotine addiction [R].

  • Significant increase in smoking quantity (GA slightly less increase than with GG) [R].

    Increased risk for developing lung cancer (GG and GA) [R]
  • Increased odds of nicotine abstinence with slow nicotine metabolizers  [R]

  • Decreased odds of nicotine abstinence with normal nicotine metabolizers [R]

The “A” allele is associated with:

  • Normal risk of development of Schizophrenia (AA) [R]

  • Normal sensitivity from nicotine (AA) [R]

This SNP is associated with (unknown which alleles):

  • Increase risk of Chronic Obstructive Pulmonary Disease (COPD) [R]

rs1317286

Parent Gene: CHRNA3

Importance: 3
Less common allele: G = 22%
More common allele: A = 78%
My Genotype: Log In
Risk Allele: A, A, A

Disease/Trait: Fev/Fec Ratio

The A allele of rs1317286 is reported to be associated with Fev/fec Ratio (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Post bronchodilator FEV1/FVC ratio in COPD.

Disease/Trait: Chronic Obstructive Pulmonary Disease

The A allele of rs1317286 is reported to be associated with Chronic Obstructive Pulmonary Disease (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Post bronchodilator FEV1/FVC ratio in COPD.

Disease/Trait: Response To Bronchodilator

The A allele of rs1317286 is reported to be associated with Response To Bronchodilator (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Post bronchodilator FEV1/FVC ratio in COPD.

Disease/Trait: Forced Expiratory Volume

The A allele of rs1317286 is reported to be associated with Forced Expiratory Volume (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Post bronchodilator FEV1.

Disease/Trait: Response To Bronchodilator

The A allele of rs1317286 is reported to be associated with Response To Bronchodilator (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Post bronchodilator FEV1.

Disease/Trait: Fev/Fec Ratio

The A allele of rs1317286 is reported to be associated with Fev/fec Ratio (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Post bronchodilator FEV1/FVC ratio.

Disease/Trait: Response To Bronchodilator

The A allele of rs1317286 is reported to be associated with Response To Bronchodilator (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Post bronchodilator FEV1/FVC ratio.