Mechanism:

  • Decreased/standard nicotinic acetylcholine receptors, increased serum albumin (affecting blood flow) (C)

  • Increased nicotinic acetylcholine receptors (T) [R]

The Minor "T" allele is associated with:

  • smoking dependence [R]

  • higher risk of lung cancer [R1, R2]

  • higher risk of lung cancer in never-smokers [R]

  • decreased forced expiratory volume per second (FEV 1), a measure of lung function [R]

  • increased susceptibility to Chronic Obstructive Pulmonary Disease (COPD) [R1, R2, R3]

  • increased susceptibility to Chronic Bronchitis [R]

Note: It is disputed whether lung cancer risk is independently increased by this SNP, or just a result of increased smoking. [R] Additionally, tests have been conducted in almost all ethnic populations, including European, African, Korean, and Japanese descent.

The Major "C" allele is associated with:

  • Proper Transportation of hormones and fatty acids [R]

  • Proper maintainance of blood pH/blood acidity level [R]

rs12914385

Parent Gene: CHRNA3

Importance: 5
Less common allele: T = 25%
More common allele: C = 75%
My Genotype: Log In
Risk Allele: T, T, T, C, T, T, T, T, T, T

Disease/Trait: Pulmonary Function Measurement

The T allele of rs12914385 is reported to be associated with Pulmonary Function Measurement (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Pulmonary function (FEV1).

Disease/Trait: Forced Expiratory Volume

The T allele of rs12914385 is reported to be associated with Forced Expiratory Volume (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Pulmonary function (FEV1).

Disease/Trait: Chronic Obstructive Pulmonary Disease

The T allele of rs12914385 is reported to be associated with Chronic Obstructive Pulmonary Disease (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Chronic obstructive pulmonary disease (moderate to severe).

Disease/Trait: Chronic Obstructive Pulmonary Disease

The T allele of rs12914385 is reported to be associated with Chronic Obstructive Pulmonary Disease (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Chronic obstructive pulmonary disease (severe).

Disease/Trait: Serum Albumin Measurement

The C allele of rs12914385 is reported to be associated with Serum Albumin Measurement (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Serum albumin level.

Disease/Trait: Chronic Obstructive Pulmonary Disease

The T allele of rs12914385 is reported to be associated with Chronic Obstructive Pulmonary Disease (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Chronic obstructive pulmonary disease.

Disease/Trait: Chronic Obstructive Pulmonary Disease

The T allele of rs12914385 is reported to be associated with Chronic Obstructive Pulmonary Disease (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Chronic bronchitis and chronic obstructive pulmonary disease (EA).

Disease/Trait: Chronic Bronchitis

The T allele of rs12914385 is reported to be associated with Chronic Bronchitis (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Chronic bronchitis and chronic obstructive pulmonary disease (EA).

Disease/Trait: Chronic Obstructive Pulmonary Disease

rs12914385 is associated with Chronic Obstructive Pulmonary Disease (R) . It is reported to increased association with Chronic bronchitis and chronic obstructive pulmonary disease. No specific risk allele was identified in the study.

Disease/Trait: Chronic Bronchitis

rs12914385 is associated with Chronic Bronchitis (R) . It is reported to increased association with Chronic bronchitis and chronic obstructive pulmonary disease. No specific risk allele was identified in the study.

Disease/Trait: Forced Expiratory Volume

The T allele of rs12914385 is reported to be associated with Forced Expiratory Volume (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Post bronchodilator FEV1.

Disease/Trait: Response To Bronchodilator

The T allele of rs12914385 is reported to be associated with Response To Bronchodilator (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Post bronchodilator FEV1.

Disease/Trait: Fev/Fec Ratio

The T allele of rs12914385 is reported to be associated with Fev/fec Ratio (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Post bronchodilator FEV1/FVC ratio in COPD.

Disease/Trait: Chronic Obstructive Pulmonary Disease

The T allele of rs12914385 is reported to be associated with Chronic Obstructive Pulmonary Disease (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Post bronchodilator FEV1/FVC ratio in COPD.

Disease/Trait: Response To Bronchodilator

The T allele of rs12914385 is reported to be associated with Response To Bronchodilator (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Post bronchodilator FEV1/FVC ratio in COPD.

Disease/Trait: Forced Expiratory Volume

rs12914385 is associated with Forced Expiratory Volume (R) . It is reported to have a 0.08249 unit decrease on Pre bronchodilator FEV1. No specific risk allele was identified in the study.

Disease/Trait: Fev/Fec Ratio

rs12914385 is associated with Fev/fec Ratio (R) . It is reported to have a 0.017509999999999998 unit decrease on Pre bronchodilator FEV1/FVC ratio. No specific risk allele was identified in the study.

Disease/Trait: Fev/Fec Ratio

The T allele of rs12914385 is reported to be associated with Fev/fec Ratio (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Post bronchodilator FEV1/FVC ratio.

Disease/Trait: Response To Bronchodilator

The T allele of rs12914385 is reported to be associated with Response To Bronchodilator (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Post bronchodilator FEV1/FVC ratio.

Disease/Trait: Smoking Behavior

The T allele of rs12914385 is reported to be associated with Smoking Behavior (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Emphysema distribution in smoking (ratio950).

Disease/Trait: Emphysema Pattern Measurement

The T allele of rs12914385 is reported to be associated with Emphysema Pattern Measurement (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Emphysema distribution in smoking (ratio950).