Mechanism:

It's thought that the C allele causes increased gene production of SIRT1 (R).

The C allele is associated with:

  • People with the C allele have an almost 30% reduced risk of dying during an 18 year follow-up study in the general population (R,R2).
  • People with a C allele had better glucose tolerance indicated by 0.34 mmol/l lower glucose levels(R).
  • Obese people with the C allele especially had better glucose tolerance (R).

The T allele is associated with:

  • TT was at a higher risk for diabetes(8.91X risk) (R).

rs12778366

Parent Gene: SIRT1

Importance: 5
Less common allele: C = 11%
More common allele: T = 89%
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