Mechanism:

  • Decreased levels of glycogen synthase kinase-3𝛃 (GSK3𝛃) protein (G).

  • Increased levels of GSK3𝛃 gene (T).

The Minor "G" allele is associated with:

  • Better behavioral performance under stress (GG) [R].

  • Greater mood stability with regard to bipolar disorders [R].

  • Reduced potential of infection caused by a pathogen-induced inflammation [R].

  • Greater blood insulin concentrations [R].

The Major "T" allele is associated with:

  • Decreased functional prefrontal cortex activity (TT) [R].

  • Increased risk for schizophrenia (TT) [R].

  • Decreased immune response to specific antigens (TT) [R].

  • Greater potential for inflammation (TT) [R].

  • Greater risk for Alzheimer’s Disease [R].

  • Some studies have associated the allele with Parkinson’s Disease [R].

  • Greater chance of muscle enlargement [R].

  • Greater risk for fat buildup around the neck (MSL) [R].

This SNP is associated with (unknown  which alleles):

  • Increased risk for diabetes [R] (probably the T allele).

rs12630592

Parent Gene: GSK3B

Importance: 4
Less common allele: G = 41%
More common allele: T = 59%
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