rs12443621 is a SNP of the TOX3 gene. It was significantly associated with increasing breast density and with increasing breast cancer risk in the Breast Cancer Association Consortium (BCAC) (OR = 1.23) [R].

The minor allele ''G''  was significantly associated with a slightly lower body mass index (= 0.043) in patients with primary breast cancer [R].

Women with at least one ''G'' allele (previously associated with increased breast cancer risk) had 3% to 4% higher mammographic densities than women with two ''A'' alleles [R].

''AG/GG'' genotypes were significantly associated with increased risk of ER positive breast cancer (OR = 1.38), compared with homozygote AA [R].

rs12443621

Parent Gene: TOX3

Importance: 2
Less common allele: G = 49%
More common allele: A = 51%
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