Mechanism:

The minor (G) allele is reported to be associated with increased levels of Striatal Dopamine D2 receptor (DRD2) [R].

  • Normal levels of DRD2 (AA) [R]
  • Potentially higher levels of DRD2 (GA) [R]
  • Abnormally high levels of DRD2 (GG) [R].

The Minor "G" allele is associated with:

  • Increased Post Traumatic Stress Disorder (PTSD) risk in Amphetamine dependent individuals. [R]
  • Increased risk of Binge Eating Disorder (BED). This could lead to obesity . [R]
  • Decreased risk of alcoholism, drug abuse, and drug addiction. [R] [R]
  • Decreased effects of antipsychotic treatments. These treatments aim to decrease DRD2 expression while the G allele will increase DRD2 expression. [R]
  • Increased symptoms of Schizophrenia if the disease is present. [R] Possible association with the onset of Schizophrenia. [R]
  • Increased response to stressful situations (avoidance learning) in the brain. [R] [R]
  • Possible increases in the working memory of the prefrontal cortex (PFC) in the brain. [R]
  • Decreased risk of autism. Because this polymorphism increases DRD2 expression, it will in turn lower risk of autism. [R]
  • Decreased risk for obesity and insulin resistance. [R]
  • An increased potential risk of developing Parkinsons disease. [R]

The Major "A" allele is associated with:

  • Increased risk of alcoholism and drug addiction. [R] [R]
  • Normal (increased) affects of antipsychotic treatments. [R]
  • Possible decreased working memory. [R]
  • Possible lower reaction to stimulus. [R] [R]

rs12364283

Parent Gene: DRD2

Importance: 4
Less common allele: G = 5%
More common allele: A = 95%
My Genotype: Log In