The C (minor) allele is associated with:

  • More mood disorders than T allele [R].

  • Increased activity in the amygdala (a region of the brain). This might increase anxiety and emotional memory [R].

The T (major) allele is associated with:

  • A good response to antidepressant therapy such as vagus stimulation, sleep deprivation and diverse antidepressant therapy (e.g., imipramine, tianeptine, duloxetine, fluoxetine, mirtazapine) [R].

  • Bipolar disorder [R,R2].

  • Individuals with suicidal tendency or other psychiatric disorders [R].


Parent Gene: BDNF

Importance: 3
Less common allele: C = 10%
More common allele: T = 90%
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