Mechanism:

AA (major) = Faster metabolizer (R)

AG = Intermediate metabolizer (R)

GG (minor) = Slower metabolizer (R)

NAT2 functions to both activate and deactivate arylamine and hydrazine drugs and carcinogens. It does this by acetylating/metabolizing the compound.  A faster metabolizer or faster acetylation will generally handle toxins better and need higher doses of certain drugs, whereas a slower metabolizer or slower acetylation will handle toxins less well and need lower doses of certain drugs.

NAT2 enzyme activates and deactivates arylamine and hydrazine drugs and carcinogens

The Major "A" allele is associated with:

  • AA=Fast metabolizer of NAT2 enzyme.

 

rs1208

Parent Gene: NAT2

Importance: 5
Less common allele: G = 32%
More common allele: A = 68%
My Genotype: Log In
Risk Allele: A

Disease/Trait: Insulin Resistance

The A allele of rs1208 is reported to be associated with Insulin Resistance (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Insulin resistance/response.