The TT genotype had 1.66 and 1.67 greater odds of having clinically significant depression than participants with the CT and CC genotypes, respectively [R]. 

The ''C'' allele was significantly associated with higher serum C-reactive protein (CRP) levels (p (trend): 0.0002), as well as with a decreased adenoma risk (OR for CT and CC vs. TT = 0.69  and 0.53, respectively, p (trend) = 0.008) [R]. 

The CC genotype boys were heavier and had larger body mass index (BMI), waist circumference (WC), hip circumference (HC), body fat percentage (BF) and waist circumference to height ratio (WHtR) than the ''T'' allele carriers. The odds ratio (OR) of larger WHtR in CC genotype boys was 2.14 (95% CI: 1.09-4.21) [R].

The TT genotype was associated with an increased risk of colon cancer (OR 1.3), The TT genotype was also associated with an increased risk of CpG island methylator phenotype (CIMP) + rectal tumors (OR 2.5) [R]. 

The association of adolescent emotional problems with the metabolic syndrome was stronger in those who were homozygous for the major allele (C) (OR=1.83) than in carriers of the ''T'' allele (OR=1.01) (p=0.05) [R].

The CC genotype significantly decreased the predictive value of forced vital capacity (FVC) in the asthma group [R]. 

Patients with the ''T'' allele (CT or TT genotype) had a higher risk of warfarin bleeding than patients with the CC genotype (adjusted OR: 5·575, P = 0·014) [R]. 

Lymph node (LN) metastasis and/or severe lymphatic invasion were observed in the C/T + T/T group, while endometrial cancer patients with the C/C genotype had no LN metastases or severe lymphatic invasion [R].

The ''T'' allele carriers had lower risk of being in the inflammatory (INF) group when C20:5n-3 and n-3 highly unsaturated FA levels were greater than the median [R].

In patients with aortic stenosis carriers of the ''T'' allele were characterized by elevated serum C-reactive protein (CRP) levels (2.53 (1.51-3.96) vs. 1.68 (0.98-2.90) mg/L, p<0.001) and a higher proportion of the severe aortic valve calcification (70.4% vs. 55.1%, p=0.01) compared with major homozygotes [R].


Parent Gene: CRP

Importance: 3
Less common allele: T = 34%
More common allele: C = 66%
My Genotype: Log In