[PMID 18381459] 829 Caucasian cases with primary epithelial ovarian cancer and 941 frequency-matched unaffected controls

Three SNPs in DNMT3A were associated with risk among multivitamin supplement users:

  • 3' untranslated region (UTR) C>G (rs13420827: OR, 0.8; 95% CI, 0.6-1.0; P interaction = 0.006; FPRP = 0.54)
  • intron 6 G>A (rs11887120: OR, 0.8; 95% CI, 0.7-1.0; P interaction = 0.007; FPRP = 0.57)
  • intron 22 A>T (rs11695471: OR, 1.2; 95% CI, 1.0-1.5; P interaction = 0.01; FPRP = 0.66)

rs11887120

Parent Gene: DNMT3A

Importance: 1
Less common allele: T = 46%
More common allele: C = 54%
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