The "C" (major) allele is associated with:

  • Increased risk of prostate cancer only in men with lower D3 protein levels, where as in the Health Professionals Follow-up Study risks tended also to be increased with carriage of the C allele, regardless of D3 levels (R).
  • SNPS in this region have been linked to higher VDR mRNA stability and higher gene transcription activity in some but not all in vitro studies (R). This means that the minor allele of this SNP may increase levels of VDR protein.

rs11574143

Parent Gene: VDR

Importance: 3
Less common allele: T = 12%
More common allele: C = 88%
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