Mechanisms:

  • Higher levels of Hypoxia-inducible factor 1-alpha (HIF1A) under normal and low oxygen conditions (AA).
  • Increased HIF1A (A)
  • Normal levels of HIF1A (G)

The Minor "A" allele is associated with:

  • Increased colon tumor localization (p = 0.016) and increased colon tumor size (p = 0.003) [R].
  • Higher risk of pancreatic cancer (p = 0.021) [R].
  • AA genotype is 1.70X more likely than GG to have cancer (Han Chinese) [R]
  • Decreased progression of renal cell carcinoma (kidney cancer) and increased survival rate from the cancer (Han Chinese) [R].
  • Less likely (0.736X) to be associated with different types of cancers (p=0.005) compared to AG/GG [R],

The Major "G" allele is associated with:

  • Normal risk of cancer [R].

This SNP is associated with (unknown which alleles):

  • Associated with breast cancer (white females) [R].
  • Contributes to the development of knee joint cartilage degeneration (osteoarthritis) (Mexican) [R].

rs11549467

Parent Gene: HIF1A

Importance: 3
Less common allele: A = 1%
More common allele: G = 99%
My Genotype: Log In