The T (minor) allele is associated with:

  • Reduced risk of type 1 and type 2 diabetes (CT,TT) [R].

  • Higher risk of developing pancreatic cancer (TT) [R].

  • Higher risk of developing distant metastasis while being treated for prostate cancer by ADT (T) [R].

  • Higher risk of developing breast and lung cancer (TT) (Asian population) [R].

  • Lower risk of developing breast and lung cancer (TT) (Caucasian population) [R].

  • Higher risk of developing foot ulcers (T) [R]

  • Increased association with power-based athletes like weightlifters and wrestlers [R, R, R].

  • Reduced respiratory gains from physical exercise training [R]

 

This SNP is associated with (unknown alleles):

  • Association with stable exertional angina  rather than acute myocardial infarction in patients with coronary artery disease [R].

  • Higher risk for developing cellulite (bacterial skin infection) [R].

rs11549465

Parent Gene: HIF1A

Importance: 5
Less common allele: T = 7%
More common allele: C = 93%
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