Mechanisms:

  • Low activity and levels of MAO-A protein (C).
  • High activity and levels of MAO-A protein (T) [R].

The Minor "T" allele is associated with:

  • Increased risk of major depressive disorder and bipolar disorder [R].
  • Increased negative symptoms of schizophrenia [R] (lack of motivation, unclear speech, slow movement) [R].
  • Improvement (remission) of ADHD symptoms in adolescents [R].
  • Poor motor control (male) [R].

The Major "C" allele is associated with:

  • Decrease in auditory hallucinations (male) [R].
  • Increased risk of Persistent smoking (in women under age 50) [R].
  • Decreased spatial memory (female) [R].
  • Reduced response to antidepressant drugs [R].

This SNP is associated with (unknown which alleles):

  • Positive and cognitive symptoms of schizophrenia [R] (hallucinations, trouble concentrating) [R].
  • Increased risk of panic disorder [R].

rs1137070

Parent Gene: MAOA

Importance: 4
Less common allele: T = 45%
More common allele: C = 55%
My Genotype: Log In