Mechanism:

CC: have fewer D2S receptors. [R]

C: slight decrease in number of D2S receptors. [R]

T: normal number of D2S receptors. [R]

 

The Minor “C” allele is associated with:

  • Increased risk of substance addiction (CC and CT). [R]

    • GA has a slightly less increased risk compared to CC.

  • Clozapine treatment-resistants for schizophrenia. [R]

 

The Major “T” allele is associated with:

  • Normal risk of substance addiction (TT). [R]

rs1125394

Parent Gene: DRD2

Importance: 1
Less common allele: C = 26%
More common allele: T = 74%
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