Mechanism:

TT: dopamine receptor sensitivity is decreased more due to Olanzapine than with the major allele [R]

C: dopamine receptor sensitivity is decreased at a normal rate with Olanzapine [R]

 

The Minor “T” allele is associated with:

  • Olanzapine treatment for Schizophrenia results in a decrease efficiency of working memory. [R]

    • Part of short-term memory

 

The Major “C” allele is associated with:

  • No effect on memory by Olanzapine treatment. [R]

rs11214606

Parent Gene: DRD2

Importance: 3
Less common allele: T = 2%
More common allele: C = 98%
My Genotype: Log In
Risk Allele:

Disease/Trait: Short-Term Memory

rs11214606 is associated with Short-term Memory (R) . It is reported to association with Response to antipsychotic treatment in schizophrenia (working memory) (olanzapine). No specific risk allele was identified in the study.