Carriers of the C allele demonstrated a 7% increase in LVMI (95% CI: 1%-12%, p = 0.017) compared to non-carriers. The CYP17A1 polymorphism rs11191548 demonstrated a significant association with left ventricular mass index (LVMI) in patients with arterial hypertension and preserved left ventricular ejection fraction (LVEF). Thus, CYP17A1 may contribute to cardiac hypertrophy in this clinical condition [R].

rs11191548

Parent Gene: CNNM2, NT5C2

Importance: 5
Less common allele: C = 15%
More common allele: T = 85%
My Genotype: Log In
Risk Allele: T, T, T, T, T, T, T

Disease/Trait: Systolic Blood Pressure

The T allele of rs11191548 is reported to be associated with Systolic Blood Pressure (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Systolic blood pressure.

Disease/Trait: Pulse Pressure Measurement

The T allele of rs11191548 is reported to be associated with Pulse Pressure Measurement (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Blood pressure (Pulse Pressure).

Disease/Trait: Systolic Blood Pressure

The T allele of rs11191548 is reported to be associated with Systolic Blood Pressure (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Systolic blood pressure.

Disease/Trait: Systolic Blood Pressure

The T allele of rs11191548 is reported to be associated with Systolic Blood Pressure (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Blood pressure (Systolic).

Disease/Trait: Diastolic Blood Pressure

The T allele of rs11191548 is reported to be associated with Diastolic Blood Pressure (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Blood pressure (Diastolic).

Disease/Trait: Systolic Blood Pressure

The T allele of rs11191548 is reported to be associated with Systolic Blood Pressure (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Systolic blood pressure.

Disease/Trait: Systolic Blood Pressure

The T allele of rs11191548 is reported to be associated with Systolic Blood Pressure (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Systolic blood pressure (East Asians).