The A (minor) allele is associated with:

  • A= lower production of TPH2 protein and therefore less serotonin [R].
  • Decreased scores on a go-no go task, which measures a participant's capacity for sustained attention and response control/inhibition [R].
  • 1.5X risk for bipolar disorder (883 Russian patients) (R).
  • Decreased cortisol and ACTH stimulation (R). 


Parent Gene: TPH2

Importance: 4
Less common allele: A = 15%
More common allele: T = 85%
My Genotype: Log In