Homozygote carriers of G-allele had reduced bone mineral density (BMD) at baseline (P = 0.007 for lumbar spine (LS)-BMD; P = 0.008 for femoral neck (FN)-BMD), whereas homozygotes for T allele had increased BMD (P = 0.007 for LS-BMD) [R].

An allele dose effect with bone mineral density (BMD) of lumbar spine has been exhibited by major allele G  (GG: 0.86 g/cm(2), GT: 0.91 g/cm(2)) [R].




Parent Gene: COL1A1

Importance: 2
Less common allele: A = 26%
More common allele: C = 74%
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