Subjects with the GG genotype exhibited higher serum follicle stimulating hormone (FSH) levels (3.37 +/- 1.79 IU/l, n = 423) compared with heterozygotes (2.84 +/- 1.54 IU/l, n = 125) (P = 0.0005), the group of ''T'' allele carriers (GT+TT, 2.78 +/- 1.51 IU/l, n = 131) (P = 0.0005) and TT-homozygotes (2.02 +/- 0.81 IU/L, n = 6) (P = 0.031) [R].

The ''T'' allele was associated with reduced serum follicle stimulating hormone (FSH) (P = 1.20 x 10(-6)) as well as with low FSH to luteinizing hormone (LH) ratio in infertile men [R].

''T'' allele showed significant dosage effects for FSH (-0.51 U/liter per T-allele), LH (0.28 U/liter), and bitesticular volume (-3.2 ml). TT carriers were significantly more prevalent among men with lower sperm counts [R].

TT genotype was strongly associated with elevated follicle stimulating hormone (FSH) in women (TT-homozygosity effect 2.05 U/liter, P = 0.003) [R].

 

 

rs10835638

Parent Gene: FSHB

Importance: 2
Less common allele: T = 8%
More common allele: G = 92%
My Genotype: Log In