rs10759932 is a SNP in the toll-like receptor 4 TLR4 gene.

A study of 109 pregnant women focusing on TLR4 SNPs associated with chorionic plate inflammation concluded that rs10759932 was associated with increased risk when present in the mother's genome. The risk allele's increased odds ratio for clinically significant inflammation was 5.2 (CI: 3.2-6.4, p = .006) [PMID 18928988]

[PMID 19741468] Impact of Polymorphisms of TLR4/CD14 and TLR3 on Acute Rejection in Kidney Transplantation

[PMID 20109750] Host-microbial interactions in childhood atopy: Toll-like receptor 4 (TLR4), CD14, and fecal Escherichia coli

[PMID 20685742] Toll-like receptor 2 and 4 genes influence susceptibility to adverse effects of traffic-related air pollution on childhood asthma

[PMID 21081146] Impact of Toll-like receptor 4 polymorphisms on risk of cancer

[PMID 17301271] Toll-like receptor 4 genetic variation and advanced prostate cancer risk.

[PMID 17699831] Toll-like receptor 4 polymorphism associated with the response to whole-cell pertussis vaccination in children from the KOALA study.

[PMID 18396467] Genetic variation and haplotype structures of innate immunity genes in eastern India.

[PMID 19505919] Toll-like receptor signaling pathway variants and prostate cancer mortality.

[PMID 20200442] Sequence variants in the TLR4 and TLR6-1-10 genes and prostate cancer risk. Results based on pooled analysis from three independent studies.

[PMID 24108365] Polymorphism -2604G>A variants in TLR4 promoter are associated with different gene expression level in peripheral blood of atherosclerotic patients

[PMID 23161283] SNPs in toll-like receptor (TLR) genes as new genetic alterations associated with congenital toxoplasmosis?

[PMID 24929142] Genetic polymorphisms in the Toll-like receptor signalling pathway in Helicobacter pylori infection and related gastric cancer

[PMID 24269697] TLR4 polymorphisms associated with developing gastric pre-cancer lesions in a Chinese Han population

[PMID 25217737] Toll-Like Receptor 4 Polymorphisms in Gram-Negative Bacterial Infections of Han Chinese Neonates

[PMID 25394369] The Association of Polymorphisms of TLR4 and CD14 Genes with Susceptibility to Sepsis in a Chinese Population

[PMID 25928077] Screening toll-like receptor markers to predict latent tuberculosis infection and subsequent tuberculosis disease in a Chinese population

[PMID 25360682] Polymorphisms of an innate immune gene, toll-like receptor 4, and aggressive prostate cancer risk: a systematic review and meta-analysis


Parent Gene: TLR4

Importance: 1
Less common allele: C = 18%
More common allele: T = 82%
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