rs1064039, also known as G73A, Ala25Thr or A25T, is a variant in the cystatin C CST3 gene.

A relatively small study (167 patients) concluded that rs1064039(A;A) genotypes had about a 3 fold increase in risk for exudative age-related macular degeneration (ARMD).[Alzheimer's disease in Caucasians, no increased risk was seen in Asians.[PMID 22435454]

[PMID 18830724] Assessment of Alzheimer's disease case-control associations using family-based methods.

[PMID 22435454] Meta-Analysis of the Cystatin C(CST3) Gene G73A Polymorphism and Susceptibility to Alzheimer's Disease.


Parent Gene: CST3

Importance: 1
Less common allele: T = 21%
More common allele: C = 79%
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