Rs1062613 (C178T, Pro16Ser) is located within the 5' UTR of HTR3A and may effect HTR3A expression.

[PMID 11505217] reporter constructs containing the T allele showed increased HTR3A expression compared to the C allele

[PMID 14557147] CC and CT carriers associated with higher harm avoidance (p = 0.04) scores in 2 sample groups of Swedish women (366 in total), and non-conformity in 1 sample

[PMID 18359159] no significant association between treatment-resistant schizophrenia and Rs1062613, however, maintenance neuroleptic dose was significantly higher for TT carriers (p = 0.041)


[PMID 20168265] Influence of serotonin 3A and 3B receptor genes on clozapine treatment response in schizophrenia

[PMID 21420406] The HTR3A polymorphism c. -42C>T is associated with amygdala responsiveness in patients with irritable bowel syndrome.

[PMID 22700043] Outcome definitions and clinical predictors influence pharmacogenetic associations between HTR3A gene polymorphisms and response to clozapine in patients with schizophrenia

[PMID 23290502] Serotonin transporter and receptor genes significantly impact nicotine dependence through genetic interactions in both European American and African American smokers


Parent Gene: HTR3A

Importance: 3
Less common allele: T = 25%
More common allele: C = 75%
My Genotype: Log In