Rs1062613 (C178T, Pro16Ser) is located within the 5' UTR of HTR3A and may effect HTR3A expression.
[PMID 11505217] reporter constructs containing the T allele showed increased HTR3A expression compared to the C allele
[PMID 14557147] CC and CT carriers associated with higher harm avoidance (p = 0.04) scores in 2 sample groups of Swedish women (366 in total), and non-conformity in 1 sample
[PMID 18359159] no significant association between treatment-resistant schizophrenia and Rs1062613, however, maintenance neuroleptic dose was significantly higher for TT carriers (p = 0.041)
[PMID 21420406] The HTR3A polymorphism c. -42C>T is associated with amygdala responsiveness in patients with irritable bowel syndrome.
[PMID 22700043] Outcome definitions and clinical predictors influence pharmacogenetic associations between HTR3A gene polymorphisms and response to clozapine in patients with schizophrenia