rs1039559 is a SNP in the TLR6 gene. It is shown to be associated with hay fever and sensitisation.

The presence of two or more older siblings increased the risk of developing high total immunoglobulin (Ig)E levels at different ages. This risk increased further in children aged 1-2 yrs carrying the minor allele ''G'' [R]. 

For those with childhood farm exposure, carriers of the ''A'' allele (p-interaction = 0.009) were associated with lower risk of early-onset asthma [R].



Parent Gene: TLR6

Importance: 2
Less common allele: G = 33%
More common allele: A = 67%
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