rs1019385 ( -200G/T ) is a SNP in close proximity to GRIN2B (Glutamate [NMDA] receptor subunit epsilon-2).

[PMID 20421849] significant effect of rs1019385 genotype on habituation after acoustic stimulus noted

[PMID 19324536] small preliminary study (consisting of 16 psychotropic-naive pediatric patients) observed a significant association between rs1019385 genotype and anterior cingulate cortex (ACC) glutamatergic concentration (but not occipital glutamatergic concentration)

[PMID 16266783] Analysis of correlation between serum D-serine levels and functional promoter polymorphisms of GRIN2A and GRIN2B genes.

[PMID 18303265] Association analysis of GRIN2B, encoding N-methyl-D-aspartate receptor 2B subunit, and Alzheimer's disease.

[PMID 18983893] Association between NR2B subunit gene (GRIN2B) promoter polymorphisms and sporadic Alzheimer's disease in the North Chinese population.

[PMID 19911060] Persistence criteria for susceptibility genes for schizophrenia: a discussion from an evolutionary viewpoint.


Parent Gene: GRIN2B

Importance: 1
Less common allele: A = 43%
More common allele: C = 57%
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