rs10046 is a SNP in the CYP19A1 gene. It can be used as genetic marker for gender-specific essential hypertension (EH) [R].

Both systolic blood pressure (SBP) and diastolic blood pressure (DBP) levels were higher in male subjects with the A/A genotype than in male subjects without A/A genotype [R].

The G/G genotype was associated with a greater frequency of miscarriages (P = 0.017) [R].

Serum prostate specific antigen (PSA) (a specific benign prostatic hyperplasia parameter) was higher in men carrying the heterozygous genotype than in those with the GG-genotype (P = 0.012) [R].

Those homozygous for the major allele ''G'' were at a lower risk of prostate cancer despite less than 60 mg isoflavones/day [R].

The frequencies of heterozygous GA and variant AA genotypes were significantly higher (p<0.001) in migraine patients as compared to healthy controls. GA is associated with a migraine without aura (MO) only and AA genotype is associated with migraines without and with aura (MA) [R].

AG + AA genotypes were associated with both overall cancer risk (AA + AG vs. AA a OR = 1.73) and premenopausal cancer risk (AA+ AG vs. AA a OR = 1.78) [R]. 

A significantly increased number of patients with the AA genotype develop breast cancer under the age of 50 (41.8% of AA patients, compared to 26.6% of G carriers; p = 0.018) [R].

''A'' allele was marginally associated with increased risk of endometrial cancer (OR =1.20, p=0.06) [R].

GG genotype in females was associated with higher apolipoprotein (apo) B than GA + AA genotypes, independent of age and body mass index (BMI). Among premenopausal females, insulin levels (p = 0.007), BMI (p = 0.05) and homeostasis model assessment (HOMA) index (p = 0.034) were higher in ''G'' homozygotes than in ''A'' allele carriers. However, AA genotype contributed to hypertension at an OR 1.80, independently of age, body mass index (BMI), and other confounders, in males alone [R].

 

rs10046

Parent Gene: CYP19A1

Importance: 2
Less common allele: A = 36%
More common allele: G = 64%
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