Mechanism:

  • Rs1004446 (G to A) is a variation downstream (not in final product) of IGF2 . IGF-2 is involved in growth and repair of cells.
  • Higher IGF-2 (G) (R).
  • Lower IGF-2 (A) (R).

The Minor "A" allele is associated with (lower IGF-2):

  • Decreased risk of endometrial cancer (R).

The Major "G" allele is associated with:

  • Higher blood IGF-2 levels (R).
  • Increased risk of prostate cancer (R).
  • Increased risk of Beckwith-Wiedemann Syndrome (R).
  • Increased risk of type II diabetes (R).
  • Increased risk of type I diabetes (R).

rs1004446

Parent Gene: IGF2, INS-IGF2

Importance: 3
Less common allele: A = 33%
More common allele: G = 67%
My Genotype: Log In
Risk Allele: C, G

Disease/Trait: Type I Diabetes Mellitus

The C allele of rs1004446 is reported to be associated with Type I Diabetes Mellitus (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Type 1 diabetes.

Disease/Trait: Type I Diabetes Mellitus

The G allele of rs1004446 is reported to be associated with Type I Diabetes Mellitus (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Type 1 diabetes.