An agent or drug which suppresses the activity and/or downstream effects of one or both of the gonadotropins, follicle-stimulating hormone (FSH) and luteinizing hormone (LH). Used in treatment of hormonally-sensitive cancers, to delay precocious puberty and puberty in transgender youth, as a form of chemical castration to reduce the sex drives of individuals (namely males) with hypersexuality or pedophilia, and to treat estrogen-associated conditions in women such as menorrhagia and endometriosis.