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ZP3 (Zona pellucida glycoprotein 3)

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The Function of ZP3

The mammalian zona pellucida, which mediates species-specific sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP3 is essential for sperm binding and zona matrix formation.

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Protein names

Recommended name:

Zona pellucida sperm-binding protein 3

Alternative name(s):

Sperm receptor
ZP3A/ZP3B
Zona pellucida glycoprotein 3
Zp-3
Zona pellucida protein C

ZP3 SNPs

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  1. RS6465122 (ZP3) ??

Top Gene-Substance Interactions

Substances That Increase ZP3

Substances Interaction Organism Category

Substances That Decrease ZP3

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

Tissue specificity:

Oocytes.

Molecular Function:

  • Signal Transducer Activity
  • Manganese Ion Transmembrane Transporter Activity
  • Store-Operated Calcium Channel Activity
  • Carbohydrate Binding
  • Acrosin Binding

Biological Processes:

  • Blastocyst Formation
  • Humoral Immune Response Mediated By Circulating Immunoglobulin
  • Positive Regulation Of Leukocyte Migration
  • Positive Regulation Of Humoral Immune Response
  • Manganese Ion Transport
  • Intracellular Protein Transport
  • Binding Of Sperm To Zona Pellucida
  • Positive Regulation Of Phosphatidylinositol Biosynthetic Process
  • Positive Regulation Of Interferon-Gamma Production
  • Positive Regulation Of Interleukin-4 Production
  • Intracellular Signal Transduction
  • Positive Regulation Of T Cell Proliferation
  • Positive Regulation Of Protein Kinase Activity
  • Negative Regulation Of Transcription, Dna-Templated
  • Positive Regulation Of Transcription, Dna-Templated
  • Phosphatidylinositol-Mediated Signaling
  • Oocyte Development
  • Positive Regulation Of Inflammatory Response
  • Positive Regulation Of Protein Kinase B Signaling
  • Protein Kinase C Signaling
  • Positive Regulation Of Calcium Ion Import
  • Positive Regulation Of Acrosome Reaction
  • Negative Regulation Of Binding Of Sperm To Zona Pellucida
  • Positive Regulation Of Ovarian Follicle Development
  • Positive Regulation Of Antral Ovarian Follicle Growth
  • Egg Coat Formation
  • Positive Regulation Of Acrosomal Vesicle Exocytosis
  • Positive Regulation Of Type Iv Hypersensitivity
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| CB1_000518033| EGK_13577| glycoprotein hZP3| gp41| GW7_12435| I79_007269| N307_03385| N312_05688| N328_05878| N341_08498| PAL_GLEAN10012029| PANDA_015436| sperm receptor| XlZPC| zona pellucida 3| zona pellucida 3 glycoprotein| zona pellucida 3 glycoprotein (sperm receptor)| zona pellucida C| zona pellucida C protein| zona pellucida glycoprotein 3.2| zona pellucida glycoprotein 3A (sperm receptor)| zona pellucida glycoprotein 3B| zona pellucida glycoprotein 3-beta| zona pellucida glycoprotein 3 preproprotein| zona pellucida glycoprotein 3 (sperm receptor)| zona pellucida glycoprotein C| zona pellucida glycoprotein ZP3| zona pellucida glycoprotein ZP3B| zona pellucida glycoprotein ZP3-beta| zona pellucida protein 3-beta| zona pellucida protein C| Zona pellucida sperm-binding protein 3| Zp-3| zp3.2| ZP3A| ZP3A/ZP3B| Zp-3B| ZP3B| zp-3-beta| zp3-beta| ZPC| ZPC protein| zp3

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