The Function of ZP3
The mammalian zona pellucida, which mediates species-specific sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP3 is essential for sperm binding and zona matrix formation.
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Protein names
Recommended name:
Zona pellucida sperm-binding protein 3Alternative name(s):
Sperm receptorZP3A/ZP3B
Zona pellucida glycoprotein 3
Zp-3
Zona pellucida protein C
- RS6465122 (ZP3) ??
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Top Gene-Substance Interactions
Substances That Increase ZP3
| Substances | Interaction | Organism | Category |
Substances That Decrease ZP3
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Oocytes.
Molecular Function:
- Acrosin Binding
- Carbohydrate Binding
- Manganese Ion Transmembrane Transporter Activity
- Signal Transducer Activity
- Store-Operated Calcium Channel Activity
Biological Processes:
- Binding Of Sperm To Zona Pellucida
- Blastocyst Formation
- Egg Coat Formation
- Humoral Immune Response Mediated By Circulating Immunoglobulin
- Intracellular Protein Transport
- Intracellular Signal Transduction
- Manganese Ion Transport
- Negative Regulation Of Binding Of Sperm To Zona Pellucida
- Negative Regulation Of Transcription, Dna-Templated
- Oocyte Development
- Phosphatidylinositol-Mediated Signaling
- Positive Regulation Of Acrosomal Vesicle Exocytosis
- Positive Regulation Of Acrosome Reaction
- Positive Regulation Of Antral Ovarian Follicle Growth
- Positive Regulation Of Calcium Ion Import
- Positive Regulation Of Humoral Immune Response
- Positive Regulation Of Inflammatory Response
- Positive Regulation Of Interferon-Gamma Production
- Positive Regulation Of Interleukin-4 Production
- Positive Regulation Of Leukocyte Migration
- Positive Regulation Of Ovarian Follicle Development
- Positive Regulation Of Phosphatidylinositol Biosynthetic Process
- Positive Regulation Of Protein Kinase Activity
- Positive Regulation Of Protein Kinase B Signaling
- Positive Regulation Of T Cell Proliferation
- Positive Regulation Of Transcription, Dna-Templated
- Positive Regulation Of Type Iv Hypersensitivity
- Protein Kinase C Signaling