The Function of ZKSCAN3
Transcriptional factor that binds to the consensus sequence 5'-[GT][AG][AGT]GGGG-3' and acts as a repressor of autophagy. Specifically represses expression of genes involved in autophagy and lysosome biogenesis/function such as MAP1LC3B, ULK1 or WIPI2. Associates with chromatin at the ITGB4 and VEGF promoters. Also acts as a transcription activator and promotes cancer cell progression and/or migation in various tumors and myelomas.
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Protein names
Recommended name:
Zinc finger protein with KRAB and SCAN domains 3Alternative name(s):
Zinc finger and SCAN domain-containing protein 13Zinc finger protein 306
Zinc finger protein 309
Zinc finger protein 47 homolog
Zf47
Zfp-47
- RS6903823 (ZKSCAN3) ??
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Top Gene-Substance Interactions
Substances That Increase ZKSCAN3
| Substances | Interaction | Organism | Category |
Substances That Decrease ZKSCAN3
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Gene Pathways:
Induction:
Overexpressed in various tumors, such as multiple myeloma, colorectal and prostate cancers (at protein level).
Molecular Function:
- Rna Polymerase Ii Core Promoter Proximal Region Sequence-Specific Dna Binding
- Transcriptional Repressor Activity, Rna Polymerase Ii Core Promoter Proximal Region Sequence-Specific Binding
- Dna Binding
- Chromatin Binding
- Transcription Factor Activity, Sequence-Specific Dna Binding
- Sequence-Specific Dna Binding
- Metal Ion Binding
Biological Processes:
- Negative Regulation Of Transcription From Rna Polymerase Ii Promoter
- Transcription, Dna-Templated
- Autophagy
- Lysosome Organization
- Negative Regulation Of Autophagy
- Negative Regulation Of Transcription, Dna-Templated
- Positive Regulation Of Transcription, Dna-Templated
- Negative Regulation Of Cellular Senescence