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  3. ZKSCAN3

ZKSCAN3 (Zinc finger with KRAB and SCAN domains 3)

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The Function of ZKSCAN3

Transcriptional factor that binds to the consensus sequence 5'-[GT][AG][AGT]GGGG-3' and acts as a repressor of autophagy. Specifically represses expression of genes involved in autophagy and lysosome biogenesis/function such as MAP1LC3B, ULK1 or WIPI2. Associates with chromatin at the ITGB4 and VEGF promoters. Also acts as a transcription activator and promotes cancer cell progression and/or migation in various tumors and myelomas.

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Protein names

Recommended name:

Zinc finger protein with KRAB and SCAN domains 3

Alternative name(s):

Zinc finger and SCAN domain-containing protein 13
Zinc finger protein 306
Zinc finger protein 309
Zinc finger protein 47 homolog
Zf47
Zfp-47

ZKSCAN3 SNPs

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  1. RS6903823 (ZKSCAN3) ??

Top Gene-Substance Interactions

Substances That Increase ZKSCAN3

Substances Interaction Organism Category

Substances That Decrease ZKSCAN3

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • RORalpha1
  • p53
  • CREB
  • deltaCREB
  • STAT5A
  • Roaz
  • Nkx5-1
  • Bach2

Gene Pathways:

  • Gene Expression

Induction:

Overexpressed in various tumors, such as multiple myeloma, colorectal and prostate cancers (at protein level).

Molecular Function:

  • Chromatin Binding
  • Dna Binding
  • Metal Ion Binding
  • Rna Polymerase Ii Core Promoter Proximal Region Sequence-Specific Dna Binding
  • Sequence-Specific Dna Binding
  • Transcriptional Repressor Activity, Rna Polymerase Ii Core Promoter Proximal Region Sequence-Specific Binding
  • Transcription Factor Activity, Sequence-Specific Dna Binding

Biological Processes:

  • Autophagy
  • Lysosome Organization
  • Negative Regulation Of Autophagy
  • Negative Regulation Of Cellular Senescence
  • Negative Regulation Of Transcription, Dna-Templated
  • Negative Regulation Of Transcription From Rna Polymerase Ii Promoter
  • Positive Regulation Of Transcription, Dna-Templated
  • Transcription, Dna-Templated
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

dJ874C20.1| dJ874C20.1.| mszf35| SCAN-KRAB-zinc finger gene 1| SCAN-KRAB-zinc finger protein| Skz1| ZF47| ZFP306| Zfp307| Zfp47| Zfp-47| zinc finger and SCAN domain-containing protein 13| zinc finger protein 306| zinc finger protein 307| zinc finger protein 309| zinc finger protein 47 homolog| zinc finger protein with KRAB and SCAN domains 3| zinc finger protein zfp47| ZNF306| ZNF309| ZSCAN13| ZSCAN35| zkscan3

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