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  3. ZIC2

ZIC2 (Zic family member 2)

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The Function of ZIC2

Acts as a transcriptional activator or repressor. Plays important roles in the early stage of organogenesis of the CNS. Activates the transcription of the serotonin transporter SERT in uncrossed ipsilateral retinal ganglion cells (iRGCs) to refine eye-specific projections in primary visual targets. Its transcriptional activity is repressed by MDFIC. Involved in the formation of the ipsilateral retinal projection at the optic chiasm midline. Drives the expression of EPHB1 on ipsilaterally projecting growth cones. Binds to the minimal GLI-consensus sequence 5'-TGGGTGGTC-3'. Associates to the basal SERT promoter region from ventrotemporal retinal segments of retinal embryos.

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Protein names

Recommended name:

Zinc finger protein ZIC 2

Alternative name(s):

Zinc finger protein of the cerebellum 2

ZIC2 SNPs

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  1. RS13542 (ZIC2) ??

Top Gene-Substance Interactions

ZIC2 Interacts with These Diseases

Disease Score

Substances That Increase ZIC2

Substances Interaction Organism Category

Substances That Decrease ZIC2

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • Zic1
  • Egr-2
  • FOXC1

Gene Pathways:

  • Hedgehog signaling pathway

Molecular Function:

  • Chromatin Dna Binding
  • Dna Binding
  • Metal Ion Binding
  • Transcription Factor Activity, Sequence-Specific Dna Binding

Biological Processes:

  • Brain Development
  • Cell Differentiation
  • Negative Regulation Of Transcription, Dna-Templated
  • Positive Regulation Of Sequence-Specific Dna Binding Transcription Factor Activity
  • Positive Regulation Of Transcription, Dna-Templated
  • Transcription, Dna-Templated
  • Visual Perception
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| odd-paired homolog| AS27_01226| CB1_060782081| cerebellum zinc finger protein 2| EH28_17648| GENA 29| hpe5| Ku| kumba| M959_01967| N300_05773| N302_01251| N303_02890| N305_09245| N307_10564| PAL_GLEAN10013755| TREES_T100006218| UY3_13131| xzic2| Y1Q_023919| Z169_03610| zic2-a| zic2-b| Zic family member 2 (odd-paired homolog)| Zic family member 2 (odd-paired homolog, Drosophila)| zinc finger protein of the cerebellum 2| zinc finger protein ZIC 2| Zinc finger protein ZIC 2-B| zic2

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