The Function of ZIC2
Acts as a transcriptional activator or repressor. Plays important roles in the early stage of organogenesis of the CNS. Activates the transcription of the serotonin transporter SERT in uncrossed ipsilateral retinal ganglion cells (iRGCs) to refine eye-specific projections in primary visual targets. Its transcriptional activity is repressed by MDFIC. Involved in the formation of the ipsilateral retinal projection at the optic chiasm midline. Drives the expression of EPHB1 on ipsilaterally projecting growth cones. Binds to the minimal GLI-consensus sequence 5'-TGGGTGGTC-3'. Associates to the basal SERT promoter region from ventrotemporal retinal segments of retinal embryos.
Protein names
Recommended name:
Zinc finger protein ZIC 2Alternative name(s):
Zinc finger protein of the cerebellum 2- RS13542 (ZIC2) ??
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Top Gene-Substance Interactions
ZIC2 Interacts with These Diseases
| Disease | Score |
Substances That Increase ZIC2
| Substances | Interaction | Organism | Category |
Substances That Decrease ZIC2
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Gene Pathways:
Molecular Function:
- Dna Binding
- Transcription Factor Activity, Sequence-Specific Dna Binding
- Chromatin Dna Binding
- Metal Ion Binding
Biological Processes:
- Transcription, Dna-Templated
- Brain Development
- Visual Perception
- Cell Differentiation
- Negative Regulation Of Transcription, Dna-Templated
- Positive Regulation Of Transcription, Dna-Templated
- Positive Regulation Of Sequence-Specific Dna Binding Transcription Factor Activity