The Function of ZFP36L2
mRNA-binding protein that plays a key role in self-renewal of erythroid cells in response to glucocorticoids. Specifically binds to the AU-rich element (ARE) in the 3'-UTR of target mRNAs, promoting their deadenylation and degradation (PubMed:14981510). Specifically expressed in burst-forming unit-erythroid (BFU-E) progenitors in response to glucocorticoids and acts as a negative regulator of erythroid cell differentiation: promotes self-renewal of erythroid cells by binding mRNAs that are induced or highly expressed during terminal erythroid differentiation and promotes their degradation, preventing erythroid cell differentiation. Down-regulated during erythroid differentiation from the BFU-E stage, stabilizing mRNAs required for terminal differentiation.
Protein names
Recommended name:
mRNA decay activator protein ZFP36L2Short name:
ERF-2Alternative name(s):
Butyrate response factor 2EGF-response factor 2
TPA-induced sequence 11d
Zinc finger protein 36, C3H1 type-like 2
ZFP36-like 2
Top Gene-Substance Interactions
ZFP36L2 Interacts with These Diseases
| Disease | Score |
Substances That Increase ZFP36L2
| Substances | Interaction | Organism | Category |
Substances That Decrease ZFP36L2
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Molecular Function:
- Au-Rich Element Binding
- Dna Binding
- Metal Ion Binding
- Mrna 3'-Utr Au-Rich Region Binding
- Mrna 3'-Utr Binding
- Poly(A) Rna Binding
- Transcription Factor Activity, Sequence-Specific Dna Binding
Biological Processes:
- 3'-Utr-Mediated Mrna Destabilization
- Cell Proliferation
- Cellular Response To Epidermal Growth Factor Stimulus
- Cellular Response To Fibroblast Growth Factor Stimulus
- Cellular Response To Glucocorticoid Stimulus
- Cellular Response To Granulocyte Macrophage Colony-Stimulating Factor Stimulus
- Cellular Response To Phorbol 13-Acetate 12-Myristate
- Cellular Response To Transforming Growth Factor Beta Stimulus
- Cellular Response To Tumor Necrosis Factor
- Definitive Hemopoiesis
- Erk1 And Erk2 Cascade
- Hemopoiesis
- Mrna Catabolic Process
- Negative Regulation Of Fat Cell Differentiation
- Negative Regulation Of Mitotic Cell Cycle Phase Transition
- Negative Regulation Of Stem Cell Differentiation
- Nuclear-Transcribed Mrna Catabolic Process, Deadenylation-Dependent Decay
- Positive Regulation Of Nuclear-Transcribed Mrna Catabolic Process, Deadenylation-Dependent Decay
- Regulation Of B Cell Differentiation
- Regulation Of Mrna Stability
- Response To Wounding
- Somatic Stem Cell Division
- Somatic Stem Cell Population Maintenance
- T Cell Differentiation In Thymus