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  3. ZFP36L2

ZFP36L2 (ZFP36 ring finger protein like 2)

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The Function of ZFP36L2

mRNA-binding protein that plays a key role in self-renewal of erythroid cells in response to glucocorticoids. Specifically binds to the AU-rich element (ARE) in the 3'-UTR of target mRNAs, promoting their deadenylation and degradation (PubMed:14981510). Specifically expressed in burst-forming unit-erythroid (BFU-E) progenitors in response to glucocorticoids and acts as a negative regulator of erythroid cell differentiation: promotes self-renewal of erythroid cells by binding mRNAs that are induced or highly expressed during terminal erythroid differentiation and promotes their degradation, preventing erythroid cell differentiation. Down-regulated during erythroid differentiation from the BFU-E stage, stabilizing mRNAs required for terminal differentiation.

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Protein names

Recommended name:

mRNA decay activator protein ZFP36L2

Short name:

ERF-2

Alternative name(s):

Butyrate response factor 2
EGF-response factor 2
TPA-induced sequence 11d
Zinc finger protein 36, C3H1 type-like 2
ZFP36-like 2

Top Gene-Substance Interactions

ZFP36L2 Interacts with These Diseases

Disease Score

Substances That Increase ZFP36L2

Substances Interaction Organism Category

Substances That Decrease ZFP36L2

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • MEF-2A
  • Pax-2
  • Nkx3-1

Molecular Function:

  • Au-Rich Element Binding
  • Dna Binding
  • Metal Ion Binding
  • Mrna 3'-Utr Au-Rich Region Binding
  • Mrna 3'-Utr Binding
  • Poly(A) Rna Binding
  • Transcription Factor Activity, Sequence-Specific Dna Binding

Biological Processes:

  • 3'-Utr-Mediated Mrna Destabilization
  • Cell Proliferation
  • Cellular Response To Epidermal Growth Factor Stimulus
  • Cellular Response To Fibroblast Growth Factor Stimulus
  • Cellular Response To Glucocorticoid Stimulus
  • Cellular Response To Granulocyte Macrophage Colony-Stimulating Factor Stimulus
  • Cellular Response To Phorbol 13-Acetate 12-Myristate
  • Cellular Response To Transforming Growth Factor Beta Stimulus
  • Cellular Response To Tumor Necrosis Factor
  • Definitive Hemopoiesis
  • Erk1 And Erk2 Cascade
  • Hemopoiesis
  • Mrna Catabolic Process
  • Negative Regulation Of Fat Cell Differentiation
  • Negative Regulation Of Mitotic Cell Cycle Phase Transition
  • Negative Regulation Of Stem Cell Differentiation
  • Nuclear-Transcribed Mrna Catabolic Process, Deadenylation-Dependent Decay
  • Positive Regulation Of Nuclear-Transcribed Mrna Catabolic Process, Deadenylation-Dependent Decay
  • Regulation Of B Cell Differentiation
  • Regulation Of Mrna Stability
  • Response To Wounding
  • Somatic Stem Cell Division
  • Somatic Stem Cell Population Maintenance
  • T Cell Differentiation In Thymus
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| zinc finger protein 36, C3H type-like 1| zinc finger protein 36, C3H type-like 2| BRF2| butyrate response factor 2| c3h-3| EGF-response factor 2| EH28_05098| erf2| ERF-2| fi22c11| PAL_GLEAN10021302| RNF162C| tis11d| XC3H-3b| Y1Q_009497| zfp36l2-a| zfp36l2-b| ZFP36-like 2| ZFP36 ring finger protein-like 2| zinc finger protein 36, C3H1 type-like 2| Zinc finger protein 36, C3H1 type-like 2-B| zinc finger protein 36 C3H1 type-like 2 protein| zinc finger protein 36, C3H type-like 2-like| zinc finger protein, C3H type, 36-like 2| zfp36l2

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