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  3. ZEB2

ZEB2 (Zinc finger E-box binding homeobox 2)

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The Function of ZEB2

Transcriptional inhibitor that binds to DNA sequence 5'-CACCT-3' in different promoters. Represses transcription of E-cadherin.

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Protein names

Recommended name:

Zinc finger E-box-binding homeobox 2

Short name:

SMADIP1

Alternative name(s):

Smad-interacting protein 1
Zinc finger homeobox protein 1b

ZEB2 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS12105918 (ZEB2) ??
  2. RS12991836 (ZEB2) ??
  3. RS13382811 (ZEB2) ??
  4. RS72858496 (ZEB2) ??

Top Gene-Substance Interactions

ZEB2 Interacts with These Diseases

Disease Score

Substances That Increase ZEB2

Substances Interaction Organism Category

Substances That Decrease ZEB2

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • AP-1
  • c-Jun
  • C/EBPalpha
  • c-Fos
  • GATA-1

Molecular Function:

  • Dna Binding
  • Metal Ion Binding
  • Phosphatase Regulator Activity
  • Transcriptional Repressor Activity, Rna Polymerase Ii Transcription Regulatory Region Sequence-Specific Binding
  • Transcriptional Activator Activity, Rna Polymerase Ii Distal Enhancer Sequence-Specific Binding

Biological Processes:

  • Developmental Pigmentation
  • Melanocyte Migration
  • Negative Regulation Of Transcription From Rna Polymerase Ii Promoter
  • Nervous System Development
  • Positive Regulation Of Melanin Biosynthetic Process
  • Positive Regulation Of Melanocyte Differentiation
  • Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
  • Regulation Of Melanosome Organization
  • Transcription, Dna-Templated
  • Cell Proliferation In Forebrain
  • Collateral Sprouting
  • Corpus Callosum Morphogenesis
  • Corticospinal Tract Morphogenesis
  • Hippocampus Development
  • Mammillary Axonal Complex Development
  • Neural Crest Cell Migration
  • Neural Tube Closure
  • Positive Regulation Of Axonogenesis
  • Positive Regulation Of Jun Kinase Activity
  • Positive Regulation Of Lens Fiber Cell Differentiation
  • Positive Regulation Of Wnt Signaling Pathway
  • Somitogenesis
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| A306_03465| AS27_00522| AS28_05340| CB1_001514003| D623_10007070| GW7_05243| H920_03918| HSPC082| I79_016567| M959_11867| MDA_GLEAN10015005| N300_03033| N301_00855| N302_02271| N303_04623| N305_08567| N306_12123| N307_01532| N308_13444| N309_12413| N310_12869| N311_10106| N312_04529| N320_03457| N321_04307| N322_11833| N324_00650| N325_07691| N326_05214| N327_02759| N328_06215| N329_06623| N330_03405| N331_02209| N332_13569| N333_11955| N334_14378| N335_10844| N336_01343| N339_08459| N340_08236| PAL_GLEAN10025842| PANDA_004054| Sip1| SIP-1| smad-interacting protein 1| SMAD interacting protein 1| smad interaction protein 1| SMADIP1| TREES_T100015177| UY3_04854| XSip1| Y1Q_031769| Y956_06130| Z169_03917| ZEB2A| Zfhx1b| Zfx1b| Zfxh1b| zinc finger E-box-binding homeobox 2| zinc finger E-box binding homeobox 2a| zinc finger homeobox 1b| zinc finger homeobox protein| zinc finger homeobox protein 1b| zeb2

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