The Function of ZEB2
Transcriptional inhibitor that binds to DNA sequence 5'-CACCT-3' in different promoters. Represses transcription of E-cadherin.
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Protein names
Recommended name:
Zinc finger E-box-binding homeobox 2Short name:
SMADIP1Alternative name(s):
Smad-interacting protein 1Zinc finger homeobox protein 1b
- RS12105918 (ZEB2) ??
- RS12991836 (ZEB2) ??
- RS13382811 (ZEB2) ??
- RS72858496 (ZEB2) ??
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Top Gene-Substance Interactions
ZEB2 Interacts with These Diseases
| Disease | Score |
Substances That Increase ZEB2
| Substances | Interaction | Organism | Category |
Substances That Decrease ZEB2
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Molecular Function:
- Transcriptional Activator Activity, Rna Polymerase Ii Distal Enhancer Sequence-Specific Binding
- Transcriptional Repressor Activity, Rna Polymerase Ii Transcription Regulatory Region Sequence-Specific Binding
- Dna Binding
- Phosphatase Regulator Activity
- Metal Ion Binding
Biological Processes:
- Negative Regulation Of Transcription From Rna Polymerase Ii Promoter
- Neural Crest Cell Migration
- Somitogenesis
- Neural Tube Closure
- Transcription, Dna-Templated
- Nervous System Development
- Corpus Callosum Morphogenesis
- Hippocampus Development
- Cell Proliferation In Forebrain
- Corticospinal Tract Morphogenesis
- Positive Regulation Of Wnt Signaling Pathway
- Positive Regulation Of Jun Kinase Activity
- Positive Regulation Of Melanocyte Differentiation
- Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
- Positive Regulation Of Melanin Biosynthetic Process
- Developmental Pigmentation
- Collateral Sprouting
- Positive Regulation Of Axonogenesis
- Mammillary Axonal Complex Development
- Melanocyte Migration
- Positive Regulation Of Lens Fiber Cell Differentiation
- Regulation Of Melanosome Organization