The Function of ZEB1
Acts as a transcriptional repressor. Inhibits interleukin-2 (IL-2) gene expression. Enhances or represses the promoter activity of the ATP1A1 gene depending on the quantity of cDNA and on the cell type. Represses E-cadherin promoter and induces an epithelial-mesenchymal transition (EMT) by recruiting SMARCA4/BRG1. Represses BCL6 transcription in the presence of the corepressor CTBP1. Positively regulates neuronal differentiation. Represses RCOR1 transcription activation during neurogenesis. Represses transcription by binding to the E box (5'-CANNTG-3'). Promotes tumorigenicity by repressing stemness-inhibiting microRNAs.
Protein names
Recommended name:
Zinc finger E-box-binding homeobox 1Short name:
TCF-8Alternative name(s):
NIL-2-A zinc finger proteinNegative regulator of IL2
Transcription factor 8
Top Gene-Substance Interactions
ZEB1 Interacts with These Diseases
| Disease | Score |
Substances That Increase ZEB1
| Substances | Interaction | Organism | Category |
Substances That Decrease ZEB1
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Tissue specificity:
Colocalizes with SMARCA4/BRG1 in E-cadherin-negative cells from established lines, and stroma of normal colon as well as in de-differentiated epithelial cells at the invasion front of colorectal carcinomas (at protein level). Expressed in heart and skeletal muscle, but not in liver, spleen, or pancreas.
Molecular Function:
- Transcriptional Repressor Activity, Rna Polymerase Ii Transcription Regulatory Region Sequence-Specific Binding
- Chromatin Binding
- Transcription Factor Activity, Sequence-Specific Dna Binding
- Transcription Coactivator Activity
- Transcription Corepressor Activity
- Zinc Ion Binding
- E-Box Binding
Biological Processes:
- Negative Regulation Of Transcription From Rna Polymerase Ii Promoter
- Transcription, Dna-Templated
- Regulation Of Transcription From Rna Polymerase Ii Promoter
- Immune Response
- Pattern Specification Process
- Central Nervous System Development
- Cell Proliferation
- Negative Regulation Of Cell Proliferation
- Regulation Of Mesenchymal Cell Proliferation
- Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
- Negative Regulation Of Epithelial Cell Differentiation
- Regulation Of T Cell Differentiation In Thymus
- Positive Regulation Of Neuron Differentiation
- Negative Regulation Of Transcription, Dna-Templated
- Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
- Embryonic Camera-Type Eye Morphogenesis
- Embryonic Skeletal System Morphogenesis
- Semicircular Canal Morphogenesis
- Regulation Of Smooth Muscle Cell Differentiation
- Cartilage Development
- Cellular Response To Amino Acid Stimulus
- Cochlea Morphogenesis