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  3. ZEB1

ZEB1 (Zinc finger E-box binding homeobox 1)

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The Function of ZEB1

Acts as a transcriptional repressor. Inhibits interleukin-2 (IL-2) gene expression. Enhances or represses the promoter activity of the ATP1A1 gene depending on the quantity of cDNA and on the cell type. Represses E-cadherin promoter and induces an epithelial-mesenchymal transition (EMT) by recruiting SMARCA4/BRG1. Represses BCL6 transcription in the presence of the corepressor CTBP1. Positively regulates neuronal differentiation. Represses RCOR1 transcription activation during neurogenesis. Represses transcription by binding to the E box (5'-CANNTG-3'). Promotes tumorigenicity by repressing stemness-inhibiting microRNAs.

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Protein names

Recommended name:

Zinc finger E-box-binding homeobox 1

Short name:

TCF-8

Alternative name(s):

NIL-2-A zinc finger protein
Negative regulator of IL2
Transcription factor 8

Top Gene-Substance Interactions

ZEB1 Interacts with These Diseases

Disease Score

Substances That Increase ZEB1

Substances Interaction Organism Category

Substances That Decrease ZEB1

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • Egr-1
  • AREB6
  • p300
  • RREB-1

Tissue specificity:

Colocalizes with SMARCA4/BRG1 in E-cadherin-negative cells from established lines, and stroma of normal colon as well as in de-differentiated epithelial cells at the invasion front of colorectal carcinomas (at protein level). Expressed in heart and skeletal muscle, but not in liver, spleen, or pancreas.

Molecular Function:

  • Chromatin Binding
  • E-Box Binding
  • Transcriptional Repressor Activity, Rna Polymerase Ii Transcription Regulatory Region Sequence-Specific Binding
  • Transcription Coactivator Activity
  • Transcription Corepressor Activity
  • Transcription Factor Activity, Sequence-Specific Dna Binding
  • Zinc Ion Binding

Biological Processes:

  • Cartilage Development
  • Cell Proliferation
  • Cellular Response To Amino Acid Stimulus
  • Central Nervous System Development
  • Cochlea Morphogenesis
  • Embryonic Camera-Type Eye Morphogenesis
  • Embryonic Skeletal System Morphogenesis
  • Immune Response
  • Negative Regulation Of Cell Proliferation
  • Negative Regulation Of Epithelial Cell Differentiation
  • Negative Regulation Of Transcription, Dna-Templated
  • Negative Regulation Of Transcription From Rna Polymerase Ii Promoter
  • Pattern Specification Process
  • Positive Regulation Of Neuron Differentiation
  • Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
  • Regulation Of Mesenchymal Cell Proliferation
  • Regulation Of Smooth Muscle Cell Differentiation
  • Regulation Of T Cell Differentiation In Thymus
  • Regulation Of Transcription From Rna Polymerase Ii Promoter
  • Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
  • Semicircular Canal Morphogenesis
  • Transcription, Dna-Templated
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| DNA-binding protein| zinc finger E-box-binding homeobox 1| A306_01569| Anapl_11134| AREB6| AS27_09214| AS28_03961| bzp| D623_10033015| delta-crystallin enhancer-binding factor| delta-crystallin enhancer binding factor 1| [delta]EF1| delta EF1| DELTAEF1| fecd6| H920_04060| I79_012175| MDA_GLEAN10008805| MEB1| N300_13633| N301_13502| N302_03983| N303_01934| N305_13145| N306_00692| N309_08003| N321_14231| N322_12125| N324_07845| N326_13430| N327_04524| N328_03381| N329_01330| N330_14172| N331_02659| N333_02730| N335_13375| N340_14492| N341_08650| negative regulator of IL2| Nil2| nil-2a| nil-2-a| NIL2A| PAL_GLEAN10005156| PANDA_009232| posterior polymorphous corneal dystrophy 3| PPCD3| Tcf18| TCF8| TCF-8| transcription factor 8| transcription factor 8 (represses interleukin 2 expression)| TREES_T100007889| Tw| twirler| UY3_11265| Y1Q_009374| Y956_00118| zeb| ZEB2| zfhep| zfhx1| Zfhx1a| Zfx1a| Zfx1ha| zinc finger E-box binding homeobox 2| zinc finger homeobox protein 1a| zinc finger homeodomain enhancer-binding protein| Zinc finger protein BZP| zeb1

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