The Function of XRCC2
Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. Part of the Rad21 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA.
Protein names
Recommended name:
DNA repair protein XRCC2Alternative name(s):
X-ray repair cross-complementing protein 2- RS10234749 (XRCC2) ??
- RS10952362 (XRCC2) ??
- RS13232006 (XRCC2) ??
- RS2040639 (XRCC2) ??
- RS3218408 (XRCC2) ??
- RS3218536 (XRCC2) ??
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Top Gene-Substance Interactions
Substances That Increase XRCC2
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Substances That Decrease XRCC2
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Advanced Summary
Covered on Genetics Home Reference: breast cancer
From NCBI Gene: This gene encodes a member of the RecA/Rad51-related protein family that participates in homologous recombination to maintain chromosome stability and repair DNA damage. This gene is involved in the repair of DNA double-strand breaks by homologous recombination and it functionally complements Chinese hamster irs1, a repair-deficient mutant that exhibits hypersensitivity to a number of different DNA-damaging agents. [provided by RefSeq, Jul 2008] From UniProt: Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. Part of the Rad21 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA.
Conditions with Increased Gene Activity
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Conditions with Decreased Gene Activity
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Technical
The following transcription factors affect gene expression:
Molecular Function:
- Recombinase Activity
- Double-Stranded Dna Binding
- Single-Stranded Dna Binding
- Atp Binding
- Dna-Dependent Atpase Activity
Biological Processes:
- Mitotic Cell Cycle
- Double-Strand Break Repair Via Homologous Recombination
- Dna Synthesis Involved In Dna Repair
- Strand Displacement
- In Utero Embryonic Development
- Somitogenesis
- Dna Repair
- Mitotic Recombination
- Meiotic Nuclear Division
- Reciprocal Meiotic Recombination
- Response To X-Ray
- Response To Ionizing Radiation
- Response To Gamma Radiation
- Multicellular Organism Growth
- Strand Invasion
- Negative Regulation Of Neuron Apoptotic Process
- Positive Regulation Of Neurogenesis
- Centrosome Organization
- Regulation Of Fibroblast Apoptotic Process
- Meiotic Dna Recombinase Assembly