• Navigation
  • Register My DNA Kit
  • Features
  • Pricing
  • FAQ
  • About
  • Labs
  • Login
  • Get started
  1. Home
  2. Genes
  3. XRCC2

XRCC2 (X-ray repair cross complementing 2)

Loading...

The Function of XRCC2

Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. Part of the Rad21 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA.

0 users want this gene increased, 0 users want it decreased

Protein names

Recommended name:

DNA repair protein XRCC2

Alternative name(s):

X-ray repair cross-complementing protein 2

XRCC2 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS10234749 (XRCC2) ??
  2. RS10952362 (XRCC2) ??
  3. RS13232006 (XRCC2) ??
  4. RS2040639 (XRCC2) ??
  5. RS3218408 (XRCC2) ??
  6. RS3218536 (XRCC2) ??

Top Gene-Substance Interactions

Substances That Increase XRCC2

Substances Interaction Organism Category

Substances That Decrease XRCC2

Substances Interaction Organism Category

Advanced Summary

     Covered on Genetics Home Reference: breast cancer

     From NCBI Gene: This gene encodes a member of the RecA/Rad51-related protein family that participates in homologous recombination to maintain chromosome stability and repair DNA damage. This gene is involved in the repair of DNA double-strand breaks by homologous recombination and it functionally complements Chinese hamster irs1, a repair-deficient mutant that exhibits hypersensitivity to a number of different DNA-damaging agents. [provided by RefSeq, Jul 2008] From UniProt: Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. Part of the Rad21 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA.

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • GR
  • GR-alpha
  • GR-beta
  • GATA-3

Molecular Function:

  • Atp Binding
  • Dna-Dependent Atpase Activity
  • Double-Stranded Dna Binding
  • Recombinase Activity
  • Single-Stranded Dna Binding

Biological Processes:

  • Centrosome Organization
  • Dna Repair
  • Dna Synthesis Involved In Dna Repair
  • Double-Strand Break Repair Via Homologous Recombination
  • In Utero Embryonic Development
  • Meiotic Dna Recombinase Assembly
  • Meiotic Nuclear Division
  • Mitotic Cell Cycle
  • Mitotic Recombination
  • Multicellular Organism Growth
  • Negative Regulation Of Neuron Apoptotic Process
  • Positive Regulation Of Neurogenesis
  • Reciprocal Meiotic Recombination
  • Regulation Of Fibroblast Apoptotic Process
  • Response To Gamma Radiation
  • Response To Ionizing Radiation
  • Response To X-Ray
  • Somitogenesis
  • Strand Displacement
  • Strand Invasion
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| null| RAD51| X-ray repair complementing defective repair in Chinese hamster c| A306_00562| Anapl_15028| AS27_08310| AS28_01750| DNA repair protein XRCC2| DNA-repair protein XRCC2| DNA repair protein XRCC2-like protein| FANCU| GW7_02069| I79_016295| M91_18829| M959_04466| N300_07449| N301_05971| N302_04462| N303_03787| N305_11016| N306_13120| N307_06368| N308_12990| N309_14489| N310_10091| N311_09743| N312_01044| N320_12752| N321_04761| N322_04015| N324_12115| N325_11433| N326_03337| N327_02058| N328_03942| N329_09536| N330_13561| N331_10017| N332_04447| N333_10990| N334_07642| N336_07791| N339_00978| N340_12728| N341_09967| PANDA_003527| RecA| recA/RAD51 family protein| RGD1564823| X-ray repair complementing defective repair in Chinese hamster cells 2| X-ray repair cross complementing protein 2| X-ray repair cross-complementing protein 2| Y1Q_020870| Y956_14095| Z169_01075| xrcc2

Policies

  • Terms of Service
  • Platform Consent
  • Privacy Policy
  • Disclaimer

About

  • Customer Support
  • Our Team
  • Affiliate Program

Navigation

  • Homepage
  • DNA Wellness Reports
  • Personalized Genetics Blog
  • Register your DNA Test Kit
  • Login
  • Careers
GET STARTED
  • SelfDecode is a personalized health report service, which enables users to obtain detailed information and reports based on their genome. SelfDecode does not treat, diagnose or cure any conditions, but is for informational and educational purposes alone.
SelfDecode © 2021 All Rights Reserved