The Function of XDH
Key enzyme in purine degradation. Catalyzes the oxidation of hypoxanthine to xanthine. Catalyzes the oxidation of xanthine to uric acid. Contributes to the generation of reactive oxygen species. Has also low oxidase activity towards aldehydes (in vitro).
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Protein names
Recommended name:
Xanthine dehydrogenase/oxidase [Includes: Xanthine dehydrogenaseShort name:
XDAlternative name(s):
XOXanthine oxidoreductase
XOR
- RS761926 (XDH) ??
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Top Gene-Substance Interactions
XDH Interacts with These Diseases
| Disease | Score |
Substances That Increase XDH
| Substances | Interaction | Organism | Category |
Substances That Decrease XDH
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Tissue specificity:
Detected in milk (at protein level).
Gene Pathways:
Enzyme Regulation:
Can be converted from the dehydrogenase form (D) to the oxidase form (O) irreversibly by proteolysis or reversibly through the oxidation of sulfhydryl groups.
Cofactor:
Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.
Molecular Function:
- 2 Iron, 2 Sulfur Cluster Binding
- Electron Carrier Activity
- Flavin Adenine Dinucleotide Binding
- Iron Ion Binding
- Molybdopterin Cofactor Binding
- Oxidoreductase Activity, Acting On Ch-Oh Group Of Donors
- Oxidoreductase Activity, Acting On The Aldehyde Or Oxo Group Of Donors
- Protein Homodimerization Activity
- Xanthine Dehydrogenase Activity
- Xanthine Oxidase Activity
Biological Processes:
- Activation Of Cysteine-Type Endopeptidase Activity Involved In Apoptotic Process
- Lactation
- Negative Regulation Of Endothelial Cell Differentiation
- Negative Regulation Of Endothelial Cell Proliferation
- Negative Regulation Of Gene Expression
- Negative Regulation Of Protein Kinase B Signaling
- Negative Regulation Of Protein Phosphorylation
- Negative Regulation Of Vascular Endothelial Growth Factor Signaling Pathway
- Negative Regulation Of Vasculogenesis
- Positive Regulation Of P38mapk Cascade
- Positive Regulation Of Reactive Oxygen Species Metabolic Process
- Purine Nucleotide Catabolic Process
- Xanthine Catabolic Process
Drug Bank:
- Flavin Adenine Dinucleotide
- L-Carnitine
- Menadione
- Mercaptopurine
- Nitrofural
- Aldesleukin
- Azathioprine
- Carboplatin
- Carvedilol
- Chlorphenesin
- Cisplatin
- Daunorubicin
- Doxorubicin
- Febuxostat
- Procarbazine
- Pyrazinamide
- Spermine
- Trifluoperazine
- Allopurinol
- Deferoxamine