The Function of XDH
Key enzyme in purine degradation. Catalyzes the oxidation of hypoxanthine to xanthine. Catalyzes the oxidation of xanthine to uric acid. Contributes to the generation of reactive oxygen species. Has also low oxidase activity towards aldehydes (in vitro).
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Protein names
Recommended name:
Xanthine dehydrogenase/oxidase [Includes: Xanthine dehydrogenaseShort name:
XDAlternative name(s):
XOXanthine oxidoreductase
XOR
- RS761926 (XDH) ??
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Top Gene-Substance Interactions
XDH Interacts with These Diseases
| Disease | Score |
Substances That Increase XDH
| Substances | Interaction | Organism | Category |
Substances That Decrease XDH
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Detected in milk (at protein level).
Gene Pathways:
Enzyme Regulation:
Can be converted from the dehydrogenase form (D) to the oxidase form (O) irreversibly by proteolysis or reversibly through the oxidation of sulfhydryl groups.
Cofactor:
Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.
Molecular Function:
- Xanthine Dehydrogenase Activity
- Xanthine Oxidase Activity
- Iron Ion Binding
- Electron Carrier Activity
- Oxidoreductase Activity, Acting On Ch-Oh Group Of Donors
- Protein Homodimerization Activity
- Molybdopterin Cofactor Binding
- Flavin Adenine Dinucleotide Binding
- 2 Iron, 2 Sulfur Cluster Binding
- Oxidoreductase Activity, Acting On The Aldehyde Or Oxo Group Of Donors
Biological Processes:
- Negative Regulation Of Protein Phosphorylation
- Negative Regulation Of Endothelial Cell Proliferation
- Purine Nucleotide Catabolic Process
- Activation Of Cysteine-Type Endopeptidase Activity Involved In Apoptotic Process
- Lactation
- Xanthine Catabolic Process
- Negative Regulation Of Gene Expression
- Negative Regulation Of Endothelial Cell Differentiation
- Negative Regulation Of Protein Kinase B Signaling
- Positive Regulation Of P38mapk Cascade
- Negative Regulation Of Vascular Endothelial Growth Factor Signaling Pathway
- Positive Regulation Of Reactive Oxygen Species Metabolic Process
- Negative Regulation Of Vasculogenesis
Drug Bank:
- Flavin Adenine Dinucleotide
- L-Carnitine
- Menadione
- Mercaptopurine
- Nitrofural
- Aldesleukin
- Azathioprine
- Carboplatin
- Carvedilol
- Chlorphenesin
- Cisplatin
- Daunorubicin
- Doxorubicin
- Febuxostat
- Procarbazine
- Pyrazinamide
- Spermine
- Trifluoperazine
- Allopurinol
- Deferoxamine