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  3. XDH

XDH (Xanthine dehydrogenase)

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The Function of XDH

Key enzyme in purine degradation. Catalyzes the oxidation of hypoxanthine to xanthine. Catalyzes the oxidation of xanthine to uric acid. Contributes to the generation of reactive oxygen species. Has also low oxidase activity towards aldehydes (in vitro).

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Protein names

Recommended name:

Xanthine dehydrogenase/oxidase [Includes: Xanthine dehydrogenase

Short name:

XD

Alternative name(s):

XO
Xanthine oxidoreductase
XOR

XDH SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS761926 (XDH) ??

Top Gene-Substance Interactions

XDH Interacts with These Diseases

Disease Score

Substances That Increase XDH

Substances Interaction Organism Category

Substances That Decrease XDH

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • GR
  • GR-alpha
  • GR-beta
  • p53
  • AP-1
  • c-Jun
  • STAT3
  • C/EBPbeta

Tissue specificity:

Detected in milk (at protein level).

Gene Pathways:

  • Metabolic pathways
  • Metabolism
  • Peroxisome
  • Purine metabolism
  • Metabolism
  • Caffeine metabolism
  • Drug metabolism - other enzymes

Enzyme Regulation:

Can be converted from the dehydrogenase form (D) to the oxidase form (O) irreversibly by proteolysis or reversibly through the oxidation of sulfhydryl groups.

Cofactor:

Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.

Molecular Function:

  • 2 Iron, 2 Sulfur Cluster Binding
  • Electron Carrier Activity
  • Flavin Adenine Dinucleotide Binding
  • Iron Ion Binding
  • Molybdopterin Cofactor Binding
  • Oxidoreductase Activity, Acting On Ch-Oh Group Of Donors
  • Oxidoreductase Activity, Acting On The Aldehyde Or Oxo Group Of Donors
  • Protein Homodimerization Activity
  • Xanthine Dehydrogenase Activity
  • Xanthine Oxidase Activity

Biological Processes:

  • Activation Of Cysteine-Type Endopeptidase Activity Involved In Apoptotic Process
  • Lactation
  • Negative Regulation Of Endothelial Cell Differentiation
  • Negative Regulation Of Endothelial Cell Proliferation
  • Negative Regulation Of Gene Expression
  • Negative Regulation Of Protein Kinase B Signaling
  • Negative Regulation Of Protein Phosphorylation
  • Negative Regulation Of Vascular Endothelial Growth Factor Signaling Pathway
  • Negative Regulation Of Vasculogenesis
  • Positive Regulation Of P38mapk Cascade
  • Positive Regulation Of Reactive Oxygen Species Metabolic Process
  • Purine Nucleotide Catabolic Process
  • Xanthine Catabolic Process

Drug Bank:

  • Flavin Adenine Dinucleotide
  • L-Carnitine
  • Menadione
  • Mercaptopurine
  • Nitrofural
  • Aldesleukin
  • Azathioprine
  • Carboplatin
  • Carvedilol
  • Chlorphenesin
  • Cisplatin
  • Daunorubicin
  • Doxorubicin
  • Febuxostat
  • Procarbazine
  • Pyrazinamide
  • Spermine
  • Trifluoperazine
  • Allopurinol
  • Deferoxamine
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| XOR| A306_13687| ALDO2| AS27_07745| AS28_00126| CB1_000655011| D623_10019018| H920_01420| indole-3-acetaldehyde oxidase| M91_13146| M959_04549| MDA_GLEAN10025494| N300_11220| N302_00800| N303_13827| N305_04231| N306_05737| N307_08513| N308_04629| N309_09165| N310_04706| N311_03627| N320_08416| N321_11717| N322_05097| N325_05914| N326_02951| N327_02368| N328_00497| N331_12931| N332_05914| N333_13400| N334_13004| N335_14221| N336_12524| N339_02945| N340_12249| N341_00900| PAL_GLEAN10020307| PANDA_016766| TREES_T100019988| UY3_18460| XAN1| xanthine dehydrogenase/oxidase| xanthine dehydrogenase/oxidase-like protein| xanthine oxidase| xanthine oxidoreductase| XDH xanthine dehydrogenase| XO| Xox1| Xox-1| Y1Q_000338| Y956_13334| Z169_00736| xdh

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