The Function of WNT5A
Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. In the presence of FZD4, activates beta-catenin signaling. In the presence of ROR2, inhibits the canonical Wnt pathway by promoting beta-catenin degradation through a GSK3-independent pathway which involves down-regulation of beta-catenin-induced reporter gene expression. Suppression of the canonical pathway allows chondrogenesis to occur and inhibits tumor formation. Stimulates cell migration. Decreases proliferation, migration, invasiveness and clonogenicity of carcinoma cells and may act as a tumor suppressor. Mediates motility of melanoma cells. Required during embryogenesis for extension of the primary anterior-posterior axis and for outgrowth of limbs and the genital tubercle. Inhibits type II collagen expression in chondrocytes.
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Protein names
Recommended name:
Protein Wnt-5a- RS11710229 (WNT5A) ??
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Top Gene-Substance Interactions
WNT5A Interacts with These Diseases
| Disease | Score |
Substances That Increase WNT5A
| Substances | Interaction | Organism | Category |
Substances That Decrease WNT5A
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expression is increased in differentiated thyroid carcinomas compared to normal thyroid tissue and anaplastic thyroid tumors where expression is low or undetectable. Expression is found in thyrocytes but not in stromal cells (at protein level).
Gene Pathways:
Molecular Function:
- Transcription Factor Activity, Sequence-Specific Dna Binding
- Frizzled Binding
- Receptor Tyrosine Kinase-Like Orphan Receptor Binding
- Transcription Regulatory Region Dna Binding
- Receptor Agonist Activity
- Chemoattractant Activity Involved In Axon Guidance
Biological Processes:
- Activation Of Mapk Activity
- Establishment Of Planar Polarity
- Somitogenesis
- Epithelial To Mesenchymal Transition
- Positive Regulation Of Endothelial Cell Proliferation
- Heart Looping
- Positive Regulation Of Mesenchymal Cell Proliferation
- Lens Development In Camera-Type Eye
- Positive Regulation Of Cytokine Secretion Involved In Immune Response
- Type B Pancreatic Cell Development
- Planar Cell Polarity Pathway Involved In Axis Elongation
- Optic Cup Formation Involved In Camera-Type Eye Development
- Wnt Signaling Pathway, Calcium Modulating Pathway
- Activation Of Jun Kinase Activity
- Axon Guidance
- Synapse Assembly
- Hindgut Morphogenesis
- Midgut Development
- Male Gonad Development
- Anterior/Posterior Axis Specification, Embryo
- Response To Organic Substance
- Positive Regulation Of Endothelial Cell Migration
- Positive Regulation Of Peptidyl-Threonine Phosphorylation
- Positive Regulation Of T Cell Chemotaxis
- Positive Regulation Of Neuron Projection Development
- Wnt Signaling Pathway
- Olfactory Bulb Interneuron Development
- Neuron Differentiation
- Keratinocyte Differentiation
- Lung Development
- Negative Regulation Of Bmp Signaling Pathway
- Positive Regulation Of Cgmp Metabolic Process
- Prostate Gland Development
- Activation Of Protein Kinase B Activity
- Response To Estradiol
- Positive Regulation Of Interferon-Gamma Production
- Positive Regulation Of Interleukin-6 Production
- Positive Regulation Of Peptidyl-Serine Phosphorylation
- Response To Testosterone
- Cellular Protein Localization
- Non-Canonical Wnt Signaling Pathway
- Post-Anal Tail Morphogenesis
- Chemoattraction Of Serotonergic Neuron Axon
- Chemorepulsion Of Dopaminergic Neuron Axon
- Non-Canonical Wnt Signaling Pathway Via Jnk Cascade
- Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway
- Wound Healing
- Embryonic Digit Morphogenesis
- Positive Regulation Of Macrophage Activation
- Negative Regulation Of Apoptotic Process
- Estrous Cycle
- Positive Regulation Of Chemokine Biosynthetic Process
- Cell Fate Commitment
- Establishment Of Epithelial Cell Apical/Basal Polarity
- Negative Regulation Of Fat Cell Differentiation
- Positive Regulation Of Protein Catabolic Process
- Positive Regulation Of Angiogenesis
- Positive Regulation Of Ossification
- Positive Regulation Of Endocytosis
- Positive Regulation Of Meiotic Nuclear Division
- Negative Regulation Of Transcription, Dna-Templated
- Positive Regulation Of Transcription, Dna-Templated
- Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
- Negative Regulation Of Melanin Biosynthetic Process
- Positive Regulation Of Fibroblast Proliferation
- Lung Alveolus Development
- Paraxial Mesoderm Formation
- Notochord Morphogenesis
- Embryonic Skeletal System Development
- Genitalia Development
- Negative Regulation Of Axon Extension Involved In Axon Guidance
- Hypophysis Morphogenesis
- Negative Regulation Of Epithelial Cell Proliferation
- Positive Regulation Of Interleukin-1 Beta Secretion
- Positive Regulation Of Inflammatory Response
- Positive Regulation Of Nf-Kappab Transcription Factor Activity
- Cartilage Development
- Response To Glucocorticoid
- Negative Regulation Of Synapse Assembly
- Response To Hyperoxia
- Palate Development
- Convergent Extension Involved In Axis Elongation
- Convergent Extension Involved In Organogenesis
- Uterus Development
- Cervix Development
- Vagina Development
- Canonical Wnt Signaling Pathway
- Wnt Signaling Pathway, Planar Cell Polarity Pathway
- Urinary Bladder Development
- Face Development
- Positive Regulation Of Type I Interferon-Mediated Signaling Pathway
- Lateral Sprouting Involved In Mammary Gland Duct Morphogenesis
- Mesenchymal-Epithelial Cell Signaling
- Negative Regulation Of Prostatic Bud Formation
- Mammary Gland Branching Involved In Thelarche
- Epithelial Cell Proliferation Involved In Mammary Gland Duct Elongation
- Positive Regulation Of Response To Cytokine Stimulus
- Regulation Of Branching Involved In Mammary Gland Duct Morphogenesis
- Planar Cell Polarity Pathway Involved In Gastrula Mediolateral Intercalation
- Mesodermal To Mesenchymal Transition Involved In Gastrulation
- Positive Regulation Of Macrophage Cytokine Production
- Positive Regulation Of Cartilage Development
- Planar Cell Polarity Pathway Involved In Outflow Tract Morphogenesis
- Planar Cell Polarity Pathway Involved In Ventricular Septum Morphogenesis
- Planar Cell Polarity Pathway Involved In Cardiac Right Atrium Morphogenesis
- Planar Cell Polarity Pathway Involved In Cardiac Muscle Tissue Morphogenesis
- Planar Cell Polarity Pathway Involved In Pericardium Morphogenesis
- Positive Regulation Of Thymocyte Apoptotic Process
- Cellular Response To Lipopolysaccharide
- Cellular Response To Calcium Ion
- Cellular Response To Retinoic Acid
- Cellular Response To Interferon-Gamma
- Hematopoietic Stem Cell Proliferation
- Cellular Response To Transforming Growth Factor Beta Stimulus
- Negative Regulation Of Mesenchymal Cell Proliferation
- Primitive Streak Formation
- Positive Regulation Of Protein Kinase C Signaling
- Negative Regulation Of Canonical Wnt Signaling Pathway
- Cochlea Morphogenesis
- Planar Cell Polarity Pathway Involved In Neural Tube Closure
- Activation Of Gtpase Activity
- Melanocyte Proliferation
- Presynapse Assembly
- Postsynapse Assembly
- Positive Regulation Of Protein Kinase C Activity
- Positive Regulation Of Protein Localization To Synapse
- Regulation Of Cellular Protein Localization
- Excitatory Synapse Assembly
- Inhibitory Synapse Assembly
- Negative Regulation Of Cell Proliferation In Midbrain
- Planar Cell Polarity Pathway Involved In Axon Guidance
- Wnt Signaling Pathway Involved In Midbrain Dopaminergic Neuron Differentiation
- Planar Cell Polarity Pathway Involved In Midbrain Dopaminergic Neuron Differentiation
- Positive Regulation Of Cell-Cell Adhesion Mediated By Cadherin
- Positive Regulation Of Non-Canonical Wnt Signaling Pathway
- Positive Regulation Of Interleukin-8 Secretion