The Function of WFDC2
Broad range protease inhibitor.
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Protein names
Recommended name:
WAP four-disulfide core domain protein 2Alternative name(s):
Epididymal secretory protein E4Major epididymis-specific protein E4
Putative protease inhibitor WAP5
- RS11696501 (WFDC2) ??
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Top Gene-Substance Interactions
Substances That Increase WFDC2
| Substances | Interaction | Organism | Category |
Substances That Decrease WFDC2
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed in a number of normal tissues, including male reproductive system, regions of the respiratory tract and nasopharynx. Highly expressed in a number of tumors cells lines, such ovarian, colon, breast, lung and renal cells lines. Initially described as being exclusively transcribed in the epididymis.
Molecular Function:
- Aspartic-Type Endopeptidase Inhibitor Activity
- Cysteine-Type Endopeptidase Inhibitor Activity
- Endopeptidase Inhibitor Activity
- Serine-Type Endopeptidase Inhibitor Activity