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  3. WFDC2

WFDC2 (WAP four-disulfide core domain 2)

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The Function of WFDC2

Broad range protease inhibitor.

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Protein names

Recommended name:

WAP four-disulfide core domain protein 2

Alternative name(s):

Epididymal secretory protein E4
Major epididymis-specific protein E4
Putative protease inhibitor WAP5

WFDC2 SNPs

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  1. RS11696501 (WFDC2) ??

Top Gene-Substance Interactions

Substances That Increase WFDC2

Substances Interaction Organism Category

Substances That Decrease WFDC2

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • Roaz
  • AREB6
  • LyF-1
  • c-Ets-1
  • Ik-1

Tissue specificity:

Expressed in a number of normal tissues, including male reproductive system, regions of the respiratory tract and nasopharynx. Highly expressed in a number of tumors cells lines, such ovarian, colon, breast, lung and renal cells lines. Initially described as being exclusively transcribed in the epididymis.

Molecular Function:

  • Aspartic-Type Endopeptidase Inhibitor Activity
  • Cysteine-Type Endopeptidase Inhibitor Activity
  • Endopeptidase Inhibitor Activity
  • Serine-Type Endopeptidase Inhibitor Activity

Biological Processes:

  • Proteolysis
  • Spermatogenesis
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| AS27_11049| BE-20| CE4| D623_10002486| dJ461P17.6| EDDM4| EGK_02361| epididymal protein 4| epididymal protein BE-20| epididymal secretory protein 4| epididymal secretory protein E4| epididymis-specific, whey-acidic protein type, four-disulfide core| H920_08385| he4| I79_011680| Major epididymis-specific protein E4| MDA_GLEAN10002111| N305_03122| N310_01825| PAL_GLEAN10024395| PANDA_005652| putative protease inhibitor WAP5| re4| WAP5| WAP domain-containing protein HE4| WAP domain containing protein HE4-V4| WAP four-disulfide core domain 3| WAP four-disulfide core domain protein 2| WAP four-disulfide core domain protein 2-like| WAP four-disulfide core domain protein 2 pseudogene| WAP four-disulfide core domain protein 3| Waprin-Phi1| WFDC3| wfdc2

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