The Function of VTI1A
V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers. Involved in vesicular transport from the late endosomes to the trans-Golgi network. Along with VAMP7, involved in an non-conventional RAB1-dependent traffic route to the cell surface used by KCNIP1 and KCND2. May be involved in increased cytokine secretion associated with cellular senescence.
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Protein names
Recommended name:
Vesicle transport through interaction with t-SNAREs homolog 1AAlternative name(s):
Vesicle transport v-SNARE protein Vti1-like 2Vti1-rp2
- RS12241008 (VTI1A) ??
- RS17267338 (VTI1A) ??
- RS7086803 (VTI1A) ??
- RS76124550 (VTI1A) ??
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Top Gene-Substance Interactions
VTI1A Interacts with These Diseases
| Disease | Score |
Substances That Increase VTI1A
| Substances | Interaction | Organism | Category |
Substances That Decrease VTI1A
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Gene Pathways:
Molecular Function:
Biological Processes:
- Autophagy
- Er To Golgi Vesicle-Mediated Transport
- Golgi Ribbon Formation
- Golgi To Vacuole Transport
- Intra-Golgi Vesicle-Mediated Transport
- Protein Targeting To Vacuole
- Retrograde Transport, Endosome To Golgi
- Vesicle Fusion With Golgi Apparatus
- Voluntary Musculoskeletal Movement