• Navigation
  • Register My DNA Kit
  • Features
  • Pricing
  • FAQ
  • About
  • Labs
  • Login
  • Get started
  1. Home
  2. Genes
  3. VPS26A

VPS26A (VPS26, retromer complex component A)

Loading...

The Function of VPS26A

Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX3-retromer mediates the retrograde endosome-to-TGN transport of WLS distinct from the SNX-BAR retromer pathway. The SNX27-retromer is believed to be involved in endosome-to-plasma membrane trafficking and recycling of a broad spectrum of cargo proteins (Probable). The CSC seems to act as recruitment hub for other proteins, such as the WASH complex and TBC1D5 (Probable). Required for retrograde transport of lysosomal enzyme receptor IGF2R (PubMed:15078902, PubMed:15078903). Required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA) (PubMed:15247922). Required for the endosomal localization of FAM21A (indicative for the WASH complex) (PubMed:22070227). Required for the endosomal localization of TBC1D5 (PubMed:20923837). Mediates retromer cargo reognition of SORL1 and is involved in trafficking of SORL1 implicated in sorting and processing of APP (PubMed:22279231). Involved in retromer-independent lysosomal sorting of F2R (PubMed:16407403). Involved in recycling of ADRB2 (PubMed:21602791). Enhances the affinity of SNX27 for PDZ-binding motifs in cargo proteins.

0 users want this gene increased, 0 users want it decreased

Protein names

Recommended name:

Vacuolar protein sorting-associated protein 26A

Alternative name(s):

Vesicle protein sorting 26A
hVPS26

VPS26A SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS10998624 (VPS26A) ??
  2. RS1802295 (VPS26A) ??

Top Gene-Substance Interactions

Substances That Increase VPS26A

Substances Interaction Organism Category

Substances That Decrease VPS26A

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • GATA-1
  • SREBP-1a
  • SREBP-1c
  • SREBP-1b
  • c-Myb
  • USF1
  • USF-1

Gene Pathways:

  • Disease
  • Signal Transduction

Induction:

Down-regulated in Alzheimer disease. No polymorphism or variant is however associated with Alzheimer disease for VPS26A.

Molecular Function:

  • Protein Transporter Activity

Biological Processes:

  • Intracellular Protein Transport
  • Regulation Of Macroautophagy
  • Retrograde Transport, Endosome To Golgi
  • Retrograde Transport, Endosome To Plasma Membrane
  • Wnt Signaling Pathway
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| A306_12637| AS27_09460| AS28_09604| embryogenesis protein H beta 58 homolog-like| H920_01590| hb58| Hbeta58| H beta 58| h<beta>58 protein| M91_09814| M959_01265| MDA_GLEAN10020826| mVPS26| N300_07704| N301_13550| N302_07334| N303_10461| N305_07030| N306_03466| N307_01271| N308_03722| N309_15548| N310_03731| N311_05118| N312_06515| N321_11463| N322_04260| N324_05336| N325_06076| N327_00449| N328_00142| N329_08614| N330_00498| N331_06132| N333_10351| N334_10694| N335_11519| N336_00193| N339_11297| N340_12242| N341_06339| PAL_GLEAN10020550| PANDA_001611| PEP8A| putative embryogenesis protein H beta 58 homolog| UY3_02176| vacuolar protein sorting 26 A| vacuolar protein sorting 26 homolog A| vacuolar protein sorting 26 homolog A (S. pombe)| vacuolar protein sorting 26-like protein A| vacuolar protein sorting-associated protein 26A| vacuolar protein sorting-associated protein 26A-like protein| vacuole protein sorting 26| vesicle protein sorting 26A| VP26A| Vps26| vps26a-a| vps26a-b| VPS26 retromer complex comonent A| VPS26 retromer complex component A| Y1Q_006977| Y956_12771| Z169_04125| vps26a

Policies

  • Terms of Service
  • Platform Consent
  • Privacy Policy
  • Disclaimer

About

  • Customer Support
  • Our Team
  • Affiliate Program

Navigation

  • Homepage
  • DNA Wellness Reports
  • Personalized Genetics Blog
  • Register your DNA Test Kit
  • Login
  • Careers
GET STARTED
  • SelfDecode is a personalized health report service, which enables users to obtain detailed information and reports based on their genome. SelfDecode does not treat, diagnose or cure any conditions, but is for informational and educational purposes alone.
SelfDecode © 2021 All Rights Reserved