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  3. VLDLR

VLDLR (Very low density lipoprotein receptor)

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The Function of VLDLR

Binds VLDL and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. Binding to Reelin induces tyrosine phosphorylation of Dab1 and modulation of Tau phosphorylation.

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Protein names

Recommended name:

Very low-density lipoprotein receptor

Short name:

VLDL-R

Alternative name(s):

VLDL receptor

VLDLR SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS3780181 (VLDLR) ??

Top Gene-Substance Interactions

VLDLR Interacts with These Diseases

Disease Score

Substances That Increase VLDLR

Substances Interaction Organism Category

Substances That Decrease VLDLR

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • Arnt
  • Nkx2-5
  • XBP-1
  • GATA-1
  • SREBP-1a
  • YY1
  • SREBP-1c
  • SREBP-1b

Tissue specificity:

Abundant in heart and skeletal muscle; also ovary and kidney; not in liver.

Molecular Function:

  • Apolipoprotein Binding
  • Calcium-Dependent Protein Binding
  • Calcium Ion Binding
  • Glycoprotein Binding
  • Glycoprotein Transporter Activity
  • Low-Density Lipoprotein Receptor Activity
  • Reelin Receptor Activity
  • Very-Low-Density Lipoprotein Particle Binding
  • Very-Low-Density Lipoprotein Particle Receptor Activity

Biological Processes:

  • Cholesterol Metabolic Process
  • Dendrite Morphogenesis
  • Glycoprotein Transport
  • Lipid Transport
  • Memory
  • Negative Regulation Of Transcription From Rna Polymerase Ii Promoter
  • Nervous System Development
  • Positive Regulation Of Dendrite Development
  • Positive Regulation Of Protein Kinase Activity
  • Receptor-Mediated Endocytosis
  • Reelin-Mediated Signaling Pathway
  • Signal Transduction
  • Ventral Spinal Cord Development
  • Very-Low-Density Lipoprotein Particle Clearance
  • Cellular Response To Glucose Starvation
  • Cellular Response To Hypoxia
  • Cellular Response To Insulin Stimulus
  • Cellular Response To Interleukin-1
  • Cellular Response To Lipopolysaccharide
  • Cerebral Cortex Development
  • Heart Development
  • Response To Nutrient
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| VLDL| AS27_15978| AS28_06181| CAMRQ1| CARMQ1| CB1_000723005| CHRMQ1| D623_10023576| GW7_16398| lr8| MDA_GLEAN10011539| N300_04356| N302_11294| N303_07563| N305_02301| N306_04292| N307_15455| N308_15051| N309_07306| N310_13009| N312_10143| N320_07909| N325_12386| N327_11073| N328_06393| N329_00552| N330_11570| N332_05577| N333_03705| N334_04532| N335_04122| N341_07553| PAL_GLEAN10021063| PANDA_007732| TREES_T100009995| UY3_12463| Very low-density lipoprotein receptor| very low density lipoprotein receptor precursor-like protein| very low density lipoprotein (VLDL)/vitellogenin receptor| vitellogenin receptor| vitellolgenin receptor| VLDL-R| vldlrch| VLDL receptor| VTG receptor| Y1Q_007241| Y956_16449| Z169_13406| vldlr

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