The Function of VLDLR
Binds VLDL and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. Binding to Reelin induces tyrosine phosphorylation of Dab1 and modulation of Tau phosphorylation.
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Protein names
Recommended name:
Very low-density lipoprotein receptorShort name:
VLDL-RAlternative name(s):
VLDL receptor- RS3780181 (VLDLR) ??
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Top Gene-Substance Interactions
VLDLR Interacts with These Diseases
| Disease | Score |
Substances That Increase VLDLR
| Substances | Interaction | Organism | Category |
Substances That Decrease VLDLR
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Abundant in heart and skeletal muscle; also ovary and kidney; not in liver.
Molecular Function:
- Glycoprotein Binding
- Low-Density Lipoprotein Receptor Activity
- Calcium Ion Binding
- Very-Low-Density Lipoprotein Particle Receptor Activity
- Apolipoprotein Binding
- Very-Low-Density Lipoprotein Particle Binding
- Glycoprotein Transporter Activity
- Reelin Receptor Activity
- Calcium-Dependent Protein Binding
Biological Processes:
- Negative Regulation Of Transcription From Rna Polymerase Ii Promoter
- Lipid Transport
- Receptor-Mediated Endocytosis
- Signal Transduction
- Nervous System Development
- Heart Development
- Response To Nutrient
- Memory
- Cholesterol Metabolic Process
- Ventral Spinal Cord Development
- Cerebral Cortex Development
- Cellular Response To Insulin Stimulus
- Glycoprotein Transport
- Very-Low-Density Lipoprotein Particle Clearance
- Reelin-Mediated Signaling Pathway
- Cellular Response To Glucose Starvation
- Positive Regulation Of Protein Kinase Activity
- Dendrite Morphogenesis
- Cellular Response To Lipopolysaccharide
- Cellular Response To Interleukin-1
- Cellular Response To Hypoxia
- Positive Regulation Of Dendrite Development