The Function of VIMP
Involved in the degradation process of misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner. Probably acts by serving as a linker between DERL1, which mediates the retrotranslocation of misfolded proteins into the cytosol, and the ATPase complex VCP, which mediates the translocation and ubiquitination.
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Protein names
Recommended name:
Selenoprotein SAlternative name(s):
SelSVCP-interacting membrane protein
- RS28665122 (VIMP) ??
- RS9874 (VIMP) ??
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Conditions with Increased Gene Activity
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Conditions with Decreased Gene Activity
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